黄体功能不全常导致月经先期、月经过少、不孕症和胎漏、胎动不安。中医病因病机主要是肾虚、脾肾两虚或肝郁肾虚。治法以补肾健脾为主，佐以疏肝、养血。笔者团队的研究提示：补肾健脾中药复方具有升调子宫内膜、蜕膜孕激素受体（PR）表达、改善黄体效应的作用。在调经、助孕和安胎方面有较好的疗效。近年来，多项临床与实验研究亦发现，补肾健脾养血中药复方能够有效增加卵巢中窦卵泡数量，提高卵巢储备，改善卵巢功能。

Luteal phase defects（LPD）often contribute to advanced menstruation，hypomenorrhea，infertility and threatened abortion. The etiology and pathogenesis of LPD in TCM are mainly kidney deficiency，spleen and kidney deficiency or hepatic stagnation and kidney deficiency. The treatment is strengthening kidney and spleen，supplemented by soothing the liver and nourishing the blood. The research of our team suggests that Chinese herbal medicine prescription（CHMP）for strengthening kidney and spleen can increase the expression of progesterone receptor（PR）in endometrium or decidua and improve luteal effect. It has curative effect in regulating the menstrual function，preventing miscarriage and improving reproduction. Recently，a number of clinical and experimental studies have also found that the Chinese herbal compound for strengthening kidney and spleen and nourishing blood can effectively increase the number of ovarian antral follicles and improve ovarian reserve and function.