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06 March 2014, Volume 29 Issue 3 Previous Issue    Next Issue

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Progress of the research into the mechanism of pediatric acute liver failure.        YUE Wei-lin，FANG Feng 2014, 29(3): 165-170.  Abstract ( )   PDF (1124KB) ( )   The causes of acute liver failure （ALF） in children differ from those observed in adults. They can be schematically grouped into six categories： metabolic， infective， toxic， autoimmune， vascular and malignancy-induced ALF. Although the mechanisms of liver injury contributing to ALF vary due to different causes and are incompletely understood， they can be summarized into two categories： direct damage and immune-mediated liver injury. Cellular necrosis and apoptosis are the final changes of pathology. This article will review the current knowledge of the epidemiology and mechanisms of ALF in children.

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Latest advances in the diagnosis and treatment of fulminant hepatic failure in children LI Jiu-jun，ZOU Ning 2014, 29(3): 170-174.  Abstract ( )   PDF (1128KB) ( )    Fulminant hepatic failure refers to the severe liver function damage， caused by multiple factors in the onset of 8 weeks of hepatic encephalopathy and severe blood coagulation dysfunction， with onset nasty， bad prognosis， and high fatality rate. For the past many years,there have been no effective treatment methods. In recent years， artificial liver support system and liver transplantation in the treatment of fulminant liver failure have more and more been taken seriously. In this paper， the etiology， diagnosis and treatment of FHF in recent research will be summarized.

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Artificial liver support for fulminant hepatic failure in children.        ZHU Yi-min， LIU Ping-ping 2014, 29(3): 174-178.  Abstract ( )   PDF (1126KB) ( )    The true incidence of fulminant hepatic failure in the pediatric population is unknown， though fulminant hepatic failure is a rare but devastating syndrome（such as hepatic encephalopathy，DIC，MODS） that results in the death of most children affected. The mainstay of the treatment is liver transplantation，however， organ shortage limits its use.The purpose of this review is to introduce the current situation of fulminant liver failure in children，focusing on assessing the application of artificial liver，which is considered to  play a pivotal role in the treatment of fulminant liver failure.According to its classification，we mainly discussed the application of non-biological artificial liver， including its indications，advantages and disadvantages，especially the MARS. At present， the artificial liver treatment also faces many problems. None of the ELS techniques has yet been evaluated systematically in children，and survival benefits have not yet been demonstrated.

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Liver transplantation treatment for fulminant hepatic failure in children SUN Li-ying. 2014, 29(3): 178-180.  Abstract ( )   PDF (1038KB) ( )   Fulminant hepatic failure is dangerous and often fatal disorder with high mortality. Pediatric fulminant hepatic failure causeing by different etiology should be ready to do liver transplantation with assessment as soon as possible，if conservative treatment can't stop progress. At present， the technology of liver transplantation has been developed maturely. Both Living donor liver transplantation and Cadaver liver transplantation can obtain good prognosis. More importantly， it’s critical to take time to save children’s life.

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Monitoring of the blood coagulation in the blood purification treatment for fulminant hepatic failure in children HUANG Jian-ping,DU Juan. 2014, 29(3): 180-183.  Abstract ( )   PDF (1068KB) ( )   Pediatrics fulminant hepatic failure is a result of massive necrosis of liver cells in a short time， which is a serious acute illness with impaired liver function. In recent years， blood purification play a very important role in terms of the treatment of the disease. But the disease is prone to serious bleeding complications. Therefore，it is very important to conduct coagulation monitoring during blood purification

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Blood purification therapy for fulminant hepatic failure in children. WANG Mo,LI Qiu. 2014, 29(3): 184-187.  Abstract ( )   PDF (1065KB) ( )   Children with fulminant hepatic failure are in critical condition and high mortality. Blood purification technology as the most frequently used devices of non-biological artificial liver plays an effective role in helping children through the liver failure risk, liver cell regeneration and survive to liver transplantation. Artificial liver has been used for more than 50 years. New blood purification models which based on plasma exchange, hemoperfusion, hemodiafiltration andother methods have been widely used in clinical practice and become one of the important therapies for fulminant hepatic failure. Artificial liver has been used in children, but multi-center studies are needed.

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Prognosis assessment of fulminant liver failure HE Yan-xia 2014, 29(3): 187-189.  Abstract ( )   PDF (1051KB) ( )   Early and accurate prognosis assessment of patients with fulminant liver failure is difficult， but critically important for optimum clinical pathway， improving survival rate and appropriate utilization medical resources， especially liver transplantation. To date in the pediatric field there is no ideal prognosis assessment in children with fulminant liver failure. This article review the variety of prognostic criteria and scores and clinical common biochemical indicator widely used in adult and application status in pediatrics.