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06 February 2014, Volume 29 Issue 2 Previous Issue    Next Issue

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Clinical lines of thinking about inflammatory myopathies in children.        XIONG Hui. 2014, 29(2): 81-84.  Abstract ( )   PDF (1102KB) ( )   Children inflammatory myopathies are divided into autoimmunemyositises and infective myositises. Autoimmune myositises usually are called idiopathic inflammatory myopathies. Clinical diagnosis of pediatric inflammatory myopathy mainly depends on the clinical manifestation, serum creatine kinase and EMG examination, pathological examination can be further confirmed the diagnosis,the serum antibody examination will be helpful for the treatment and prognosis. The traditional JDM diagnostic criteria is Bohan and Peter standard in 1975. Keywords： idiopathic inflammatory myopathies；children；dermatomyositis；diagnosis and differential diagnosis

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Clinical manifestations and classification of inflammatory myopathies in childhood.        WANG Hua. 2014, 29(2): 84-88.  Abstract ( )   PDF (1079KB) ( )   Infective inflammatory myopathies caused by various microorgnisms are commonly seen in childhood， which is clinically characterized by muscle pain， tenderness， refusal to walk or altered gait within 1 week after acute infectious diseases. Idiopathic inflammatory myopathies are a rare form of myopathy observed during childhood. The most common inflammatory myopathies in children comprise juvenile dermatomyositis and juvenile polymyositis. The clinical manifestations include muscle pain and weakness， skin rash. The childhood inflammatory myopathies comprise a heterogeneous group with different mechanisms of affecting muscle fibers. The serum muscle enzymes， electromyography， and immune function examination should be done early for highly suspected patients.

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Diagnosis of children with idiopathic inflammatory muscle disease.        CHANG Xing-zhi. 2014, 29(2): 88-91.  Abstract ( )   PDF (1061KB) ( )   Idiopathic inflammatory sympathies are a group of rare autoimmune disorders，characterized by inflammation in striated muscle. Dermatomyositis is the most common subtype in children.Though a number of diagnostic criteria have been proposed，the diagnosis of dermatomyositis is based on a combination of clinical，laboratory and electromyography findings.Typical features are subacute-onset， proximal，symmetric muscle weakness，pathognomonic skin rashes.Muscle biopsy demonstrated inflammatory infiltrates confined to perimysium，often around blood vessels，and perifascicular muscle fiber atrophy. The uses of magnetic resonance imaging of skeletal muscles，detection of myositis-specific autoantibodies and nailfold capillaroscopy have become useful additions to our diagnostic test.

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Standardized treatment and prognosis children with inflammatory myopathy .        CHAI Yi-ming，SUN Li，ZHOU Shui-zhen. 2014, 29(2): 91-96.  Abstract ( )   PDF (877KB) ( )   Inflammatory myopathy include, infective myositis and idiopathic inflammatory myopathy. Infective myositis is mostly caused by virus， while juvenile dermatomyositis is the mainly type in idiopathic inflammatory myopathy in children.  Aggressive treatment approaches  include anti-infective and immunotherapy，which depend on pathogeny and the extent of disease.Glucocorticoids and  immunosuppressive are the first choice of immunotherapy. Delay of diagnosis and treatment，acute onset of severe symptoms and the complications are associated with poor outcome.

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Overview of the aetiology and epidemiology of the juvenile idiopathic inflammatory myopathies. Han Chun-xi 2014, 29(2): 97-100.  Abstract ( )   PDF (1080KB) ( )   The juvenile idiopathic inflammatory myopathies（JIIM） are systemic autoimmune diseases characterized by skeletal muscle weakness and characteristic rashes. Of which，juvenile dermatomyositis（JDM），juvenile polymyositis（JPM） and juvenile myositis overlapping with another autoimmune or mixed connective tissue disease（JCTM） is common clinical subgroups.To date，there is no detailed information for the aetiology of JIIM. However，the association with immune system is currently considered. Moreover，detecting the myositis-associated antibodies and myositis specific antibodies is of great help for the diagnosis and differential diagnosis of JIIM.