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06 January 2014, Volume 29 Issue 1 Previous Issue    Next Issue

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Evolution of the definition of bronchopulmonary dysplasia in preterm infants and its diagnosis.        CHANG Li-wen. 2014, 29(1): 1-4.  Abstract ( )   PDF (1011KB) ( )   Bronchopulmonary dysplasia （BPD）， also referred to as chronic lung disease （CLD） of prematurity， is the most common chronic lung disease of infants and childhood，which was first reported and defined by Northway et al. in 1967. It frequently occurs in preterm infants. This current article presents information on domestic and international incidences of BPD，clinical characteristics of “old” BPD and “new” BPD，development of definition for BPD and its diagnosis criteria.

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Etiology and risk factors of bronchopulmonary dysplasia in preterm infants.        CHEN Chao， YUAN Lin. 2014, 29(1): 5-7.  Abstract ( )   PDF (1041KB) ( )   This review is to identify the etiology and risk factors for bronchopulmonary dysplasia (BPD） in preterm infants. Studies show that BPD is a complex multifactorial disease. Preterm delivery， low birth weight， genetic predisposition， inhaled high concentration oxygen， mechanical ventilation， intrauterine infection， postnatal pulmonary infection and patent ductus arteriosus （PDA） are considered major risk factors of BPD.

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Early monitoring of bronchopulmonary dysplasia in high- risk preterm infants and its clinical significance.          XUE Xin-dong，LIU Zi-yun. 2014, 29(1): 7-11.  Abstract ( )   PDF (941KB) ( )   The etiology of bronchopulmonary dysplasia （BPD） in preterm infants is complex and the pathogenesis is not entirely clear. The definition of BPD is evolving and diagnostic criteria still need to standardize and perfect. However， a growing number of studies have found that monitoring the dynamic changes of certain inflammatory cytokines， growth factors， MMP-9 and KL-6 in umbilical cord blood， bronchoalveolar lavage fluid （BALF）and serum could help to screen high-risk newborns before clinical diagnosis of BPD. Appropriate interventions might reduce the severity of BPD， or even avoid the occurrence of the disease.

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New strategies for the prevention and treatment of bronchopulmonary dysplasia in premature infants.  DU Li-zhong. 2014, 29(1): 12-15.  Abstract ( )   PDF (1070KB) ( )   Although significant advances in respiratory care have been made in neonatal medicine， bronchopulmonary dysplasia (BPD） remains the most common serious pulmonary morbidity in premature infants. This review focuses on recent studies that evaluate the use of noninvasive ventilation support as essentially a mode for extremely preterm infants and its impact on the development of BPD. The other therapeutic strategies for preterm infant in relation to pulmonary outcomes including the use of caffeine， corticosteroids， bronchodilator， inhaled nitric oxide and permissive hypercapnia are also discussed.

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Management of children with bronchopulmonary dysplasia after discharge.        DING Guo-fang. 2014, 29(1): 15-18.  Abstract ( )   PDF (917KB) ( )   There are still problems，including difficulty in feeding baby， apnea， stunting on infants with bronchopulmonary dysplasia（BPD） after being discharged from hospital. The risk of sudden infant death syndrome also increases. Healthcare after discharge from hospital is a continuation after treatment in hospital， which is important for BPD treatment. Healthcare includes home oxygen after discharge from hospital， continuing to strengthen infant’s nutrition and feeding guidance， regular follow-up and prevention of sudden infant death syndrome.

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Long-term outcome of bronchopulmonary dysplasia in preterm infants.        ZHOU Wen-hao, CHEN Yan-lin. 2014, 29(1): 18-24.  Abstract ( )   PDF (997KB) ( )   Premature infants often suffer from chronic respiratory diseases and need supplementary oxygen at home after being discharged，and there exists increased rehospitalization， more frequent cough and wheezing symptoms， and abnormal lung function reflecting airway obstruction， hyper-responsiveness and air-trapping. Also， the neurological problems are more common in preterm survivors with bronchopulmonary dysplasia （BPD） compared to those without BPD. Severe BPD could be a predictor for poor neurodevelopmental outcome in certain type of patients.