Liver transplantation treatment for fulminant hepatic failure in children

Abstract

Abstract:

Fulminant hepatic failure is dangerous and often fatal disorder with high mortality. Pediatric fulminant hepatic failure causeing by different etiology should be ready to do liver transplantation with assessment as soon as possible，if conservative treatment can't stop progress. At present， the technology of liver transplantation has been developed maturely. Both Living donor liver transplantation and Cadaver liver transplantation can obtain good prognosis. More importantly， it’s critical to take time to save children’s life.

Key words: children , fulminant hepatic failure, liver transplantation

摘要：

暴发性肝衰竭病情凶险、进展迅速、病死率高。儿童因各种病因所致的暴发性肝衰竭若保守治疗不能阻止病情进展，应尽早进行肝脏移植的准备和评估，目前肝移植技术已经成熟，无论是亲体肝移植还是尸体供肝的肝移植均可获得良好的预后，重要的是争取时间挽救患儿生命。

关键词: 儿童, 暴发性肝衰竭, 肝移植

CLC Number:

Ｒ72

SUN Li-ying. . Liver transplantation treatment for fulminant hepatic failure in children[J]. Acta Metallurgica Sinica.

孙丽莹. 儿童暴发性肝衰竭的肝移植治疗[J]. 中国实用儿科杂志.

References

［1］    Santos DC， Martinho JM， Pacheco-Moreira LF， et al. Fulminant hepatitis failure in adults and children from a Public Hospital in Rio de Janeiro， Brazil［J］. Braz J Infect Dis， 2009 ，13（5）：323-329.

［2］    Bhatia V， Bavdekar A， Yachha SK.Management of acute liver failure in infants and children： consensus statement of the pediatric gastroenterology chapter， Indian academy of pediatrics［J］. Indian Pediatr，2013，50（5）：477-482.

［3］    Yamashiki N， Sugawara Y， Tamura S， et al. Outcomes after living donor liver transplantation for acute liver failure in Japan： results of a nationwide survey［J］. Liver Transpl，2012 ，18（9）：1069-77.

［4］    Dhawan A. Etiology and prognosis of acute liver failure in children［J］. Liver Transpl， 2008 ，14 （Suppl 2）：80-84.

［5］    Squires RH Jr， Shneider BL， Bucuvalas J， et al. Acute liver failure in children： the first 348 patients in the pediatric acute liver failure study group［J］. J Pediatr，2006 ，148（5）：652-658.

［6］    Sundaram SS， Alonso EM， Narkewicz MR， et al. Characterization and outcomes of young infants with acute liver failure［J］. J Pediatr， 2011，159（5）：813-818.

［7］    Mindikoglu AL， King D， Magder LS， et al. Valproic acid-associated acute liver failure in children： case report and analysis of liver transplantation outcomes in the United States［J］. J Pediatr，2011，158（5）：802-807.

［8］    Kelly DA. Managing liver failure［J］. Postgrad Med J，2002 ，78（925）：660-667.

［9］    Ozbay Ho?nut F， Canan O， Ozçay F， et al. Adenovirus infection as possible cause of acute liver failure in a healthy child： a case report［J］. Turk J Gastroenterol， 2008，19（4）：281-283.

［10］    Craig DG， Ford AC， Hayes PC， et al. Systematic review： prognostic tests of paracetamol-induced acute liver failure［J］. Aliment Pharmacol Ther， 2010 ，31（10）：1064-1076.

［11］    Hwang S， Lee SG， Lee YJ， et al. Postoperative changes in remnant medial segment par   of living donor livers after procurement of left lateral segment graft［J］ . Hepatogastroenterology， 2006， 53（71）： 773-777.

［12］    Yamaoka Y， Ozawa K， Tanaka A， et al. New devices for harvesting a hepatic graft from a living donor［J］ . Transplantation， 1991， 52（1）： 157-160.

［13］    de Santibañes E， McCormack L， Mattera J， et al. Partial left lateral segment transplant from a living donor ［J］. Liver Transpl， 2000， 6（1）： 108-112.

［14］    Nesher E， Island E， Tryphonopoulos P， et al. Split liver transplantation ［J］.Transplant Proc，2011，43（5）：1736-1741.

［15］    朱志军，高伟，董冲，等．劈离式肝移植58例临床分析［J］.中华器官移植杂志，2012，33（4）：195-199．

［16］    Baliga P， Alvarez S， Lindblad A， et al. Posttransplant survival in pediatric fulminant hepatic failure： the SPLIT experience［J］. Liver Transpl， 2004 ，10（11）：1364-1371.

［17］    Oh SH， Kim KM， Kim DY， et al. Long-term outcomes of pediatric living donor liver transplantation at a single institution［J］. Pediatr Transplant，2010，14（7）：870-878.

［18］    Lu CH， Tsang LL， Huang TL， et al. Biliary complications and management in pediatric living donor liver transplantation for underlying biliary atresia［J］. Transplant Proc，2012，44（2）：476-477.

（2014 - 02 - 06 收稿）

[1]	CUI Fei-fei，CHEN Chao，LIU Jing，et al. Distribution of central sleep apnea in children with obstructive sleep apnea hypopnea syndrome [J]. CJPP, 2021, 36(6): 459-462.
[2]	QUAN Min, YANG Song. Identification and treatment of acute and chronic liver diseases caused by urea cycle disorders [J]. Chinese Journal of Practical Pediatrics, 2021, 36(10): 758-762.
[3]	SUN Li-ying, ZHU Zhi-jun. Liver transplantation treatment for urea cycle disorders [J]. Chinese Journal of Practical Pediatrics, 2021, 36(10): 768-771.
[4]	XU Jing*，WANG Xiao-qiu，LI Wen-xiu，et al. A cross-sectional survey and analysis of childhood allergic diseases in two communities of Yangpu District，Shanghai [J]. CJPP, 2020, 35(9): 722-726.
[5]	DU Yu-hui*，LI Jing，LIU Cheng-jun. Relationship between glycaemic variability and outcomes in critically ill children at different age [J]. CJPP, 2020, 35(6): 471-477.
[6]	WANG Xian-zhu，LI Jiu-jun. Risk factors of purulent meningitis complicated with subdural effusion in infants and young children [J]. CJPP, 2019, 34(5): 410-413.
[7]	GUO Jiang-bo，LUO You-you. Macroamylasemia in one child and the literature review [J]. CJPP, 2019, 34(4): 315-316.
[8]	SHEN Kun-ling*，SHANG Yun-xiao，ZHANG He，et al. A multicenter，randomised，controlled clinical study on efficacy and safety of recombinant human interferon α2b spray（P.putida） in treatment of acute upper respiratory tract infection in children [J]. CJPP, 2019, 34(12): 1010-1016.
[9]	GENG Ling-ling*，MIAO Feng，ZHOU Yang，et al. Efficacy and safety of tocilizumab on refractory systemic onset juvenile idiopathic arthritis：observation on 16 cases [J]. CJPP, 2019, 34(1): 37-40.
[10]	HUANG Zong-yao*，LUO Rong，ZHANG Chuan，et al. Efficacy and safety of carnitine for epileptic children using valproic acid：An evidence-based evaluation [J]. CJPP, 2018, 33(8): 626-632.
[11]	YANG Hai-ping，LI Qiu. Obesity-related glomerulopathy in children [J]. CJPP, 2018, 33(2): 102-105.
[12]	YUAN Jing*，ZHU Ming，ZHAO Xu-sheng，et al. Analysis of the serum 25-hydroxyvitamin D level in 2416 children aged from 0 to 14 years old [J]. CJPP, 2018, 33(2): 145-147.
[13]	GAO Hui-ting，HAO Liang-chun. Iron supplement selection in the treatment of children with nutritional iron-deficiency anemia [J]. CJPP, 2018, 33(2): 148-151.
[14]	FENG Yu-ling，LIU Hai-feng. Diagnostic value of capsule endoscopy in children with gastrointestinal disorders [J]. CJPP, 2018, 33(11): 862-866.
[15]	. The establishment of diagnostic criteria for asthma in children aged＜6 years [J]. CJPP, 2018, 33(11): 870-876.