Abstract:

With the increasing prevalence of childhood overweight/obesity in the worldwide，obesity-related glomerulopathy（ORG） has become a growing concern among pediatricians. Clinical and pathologic characteristics of ORG are proteinuria，glomerulomegaly，progressive glomerulosclerosis and renal function decline. If not intervened in time，the disease may slowly progress，some of which end in end-stage renal disease. Here we review the recent advances in the pathogenesis and clinical features of ORG，as well as diagnosis and differential diagnosis and potential therapeutic targets.

Key words: obesity, obesity-related glomerulopathy（ORG）, children and adolescents

摘要：

随着儿童超重/肥胖在世界范围内发病率逐渐增高，肥胖相关肾病（ORG）越来越受到儿童肾脏专科医师的关注。ORG早期表现为蛋白尿、 肾小球肥大， 后期可出现局灶节段性肾小球硬化和肾功能下降， 如不及时干预， 可呈慢性进行性进展， 最终部分将发展至终末期肾病。文章从ORG发病机制（包括肾脏血流动力学、 神经体液、 脂代谢紊乱及其介导代谢性炎症等方面）、 临床与病理特征、 诊断与鉴别诊断、 治疗策略等方面的最新进展做系统总结。

关键词: 肥胖, 肥胖相关肾病, 儿童青少年