Abstract:

Objective　To investigate the risk factors of purulent meningitis complicated with subdural effusion in infants and young children. Methods　The clinical data of the infants and young children who were diagnosed with purulent meningitis in PICU of Shengjing Hospital of China Medical University from January 2014 to December 2017 were analyzed retrospectively. All of them were divided into 2 groups according to whether there was complication of subdural effusion. The statistical data were analyzed by SPSS 20.0 software. Results　There were significant differences in hemoglobin，C reactive protein and protein in cerebrospinal fluid between control group and subdural effusion group（P＜0.05）. Logistic regression analysis showed that hemoglobin（OR＝0.940，95%CI：0.899—0.998），C reactive protein（OR＝1.015，95%CI：1.004—1.028） and protein in cerebrospinal fluid（OR＝2.490，95%CI：1.151—6.315） were independent risk factors for purulent meningitis complicated with subdural effusion（P＜0.05）. Conclusion　Infants and young children diagnosed with purulent meningitis are with lower hemoglobin. Higher C reactive protein and higher protein in cerebrospinal fluid are likely to be complicated with subdural effusion.

Key words: purulent meningitis, subdural effusion, risk factors, infants and young children

摘要：

目的　探讨婴幼儿化脓性脑膜炎合并硬膜下积液的危险因素。方法　回顾性分析2014年1月至2017年12月中国医科大学附属盛京医院小儿重症监护病房收治的52例婴幼儿化脓性脑膜炎患儿的相关临床资料。其中合并硬膜积液者为观察组，未合并硬膜下积液者为对照组，应用SPSS 20.0软件进行统计学分析。结果　2组间外周血血红蛋白、 血清C反应蛋白、 脑脊液中蛋白定量水平差异具有统计学意义（P＜0.05）， Logistic回归分析提示外周血血红蛋白（OR＝0.940， 95%CI： 0.899～0.998）、 血清C反应蛋白（OR＝1.015， 95%CI： 1.004～1.028）及脑脊液中蛋白定量水平（OR＝2.490， 95%CI： 1.151～6.315）是合并硬膜下积液的独立危险因素（P＜0.05）。结论　诊断为化脓性脑膜炎的婴幼儿外周血血红蛋白减低，血清C反应蛋白及脑脊液蛋白定量水平增高者易合并硬膜下积液。

关键词: 化脓性脑膜炎, 硬膜下积液, 危险因素, 婴幼儿