Abstract: Neonatal inherited metabolic diseases screening is the tertiary preventive measures of prevention and control for birth defects.With the continuous increase of screening rates in various regions of China，more focus is given to the problem of how to improve the suspicious positive recall rate and implement the standardized management of confirmed children.In this paper，some suggestions will be put forward on the possible difficulties in management of screening positive and confirmed cases，in order to further improve the quality of standardized management of neonatal inherited metabolic diseases screening，diagnosis and treatment，and truly lay equal stress on screening and treatment.

Key words: neonatal, inherited metabolic diseases screening, recall rate, treatment rate

摘要： 新生儿遗传代谢病筛查是出生缺陷防控的第三级防御措施，随着我国各地筛查率不断提高，如何提高筛查阳性召回率及保证确诊患儿规范管理的问题突显。文章将针对筛查阳性及确诊病例管理中可能存在的诸多难点提出建议对策，旨在进一步提高我国新生儿遗传代谢病规范筛诊治质量，真正体现新生儿疾病筛查与诊治并重。

关键词: 新生儿, 遗传代谢病筛查, 召回率, 治疗率