Chinese Journal of Practical Pediatrics ›› 2023, Vol. 38 ›› Issue (2): 154-156.DOI: 10.19538/j.ek2023020616

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Membranous nephropathy after allogeneic hematopoietic stem cell transplantation in a child: a case report and literature review

  

  1. Department of Nephrology,Jiangxi Provincial Children's Hospital,Jiangxi  330038,China
  • Online:2023-02-06 Published:2023-03-10

儿童异基因造血干细胞移植术后并发膜性肾病1例并文献复习

  

  1. 江西省儿童医院肾内科,江西  南昌  330038
  • 通讯作者: 彭晓杰,电子信箱:wuxuan1028@163.com

Abstract: A child at 6 years and 9 months old with thalassemia was admitted to our hospital in September, 2020 due to more than 2 months of edema and over 1 moth of albuminuria,hematuria at 2 years and 10 months atter hematopoietic stem cell transplantation. After completing examination in our hospital, hypoalbuminemia and massive albuminuria were observed. Renal biopsy pathology indicated stage II membranous nephropathy (MN),which was diagnosed as secondary MN. Complete remission of urinary protein was achieved after treatment with glucocorticoid combined with tacrolimus.

Key words: hematopoietic stem cell transplantation, nephrotic syndrome, membranous nephropathy, child

摘要: 1例6岁9月龄地中海贫血患儿因“造血干细胞移植术后2年10个月,浮肿2个月余、蛋白尿、血尿1个月余”于2020年9月收治于江西省儿童医院,后在医院完善检查提示低白蛋白血症、大量蛋白尿,肾活检病理提示为II期膜性肾病,诊断为继发性膜性肾病,经糖皮质激素联合他克莫司治疗后尿蛋白达完全缓解。

关键词: 造血干细胞移植, 肾病综合征, 膜性肾病, 儿童