中国实用儿科杂志

中国实用儿科杂志 ›› 2023, Vol. 38 ›› Issue (9): 669-674.DOI: 10.19538/j.ek2023090604

• 专题笔谈 • 上一篇    下一篇

遗传因素在特应性皮炎中的研究进展

  

  1. 天津市儿童医院（天津大学儿童医院）皮肤科，天津  300134
  • 出版日期:2023-09-06 发布日期:2023-09-22
  • 通讯作者: 李钦峰，电子信箱：lyz20061217@sina.com
  • 基金资助:
    天津市卫生健康委员会科技项目（编号：ZC20062）

Research progress of genetic factors in atopic dermatitis

  1. Department of Dermatology，Tianjin Children's Hospital （Tianjin University Children's Hospital），Tianjin 300134，China
  • Online:2023-09-06 Published:2023-09-22

摘要： 特应性皮炎（AD）是由遗传、免疫和环境因素相互作用引起的慢性瘙痒性、炎症性疾病。AD具体发病病因及机制尚不完全明确，因其遗传易感性，AD的遗传和表观遗传学研究受到很多关注。遗传学研究已经确定了多个AD遗传易感基因位点及相关候选基因。例如皮肤屏障功能障碍基因、2型T辅助淋巴细胞（Th2）型免疫相关基因等。这些遗传方面的研究有利于进一步明确AD发病机制，并可能为AD的治疗提供新的方向。

关键词: 特应性皮炎, 遗传学, 先天免疫, 适应性免疫, 皮肤屏障

Abstract: Atopic dermatitis （AD） is a chronic itching and inflammatory disease caused by the interaction of genetic， immune， and environmental factors. The specific etiology and mechanism of AD are not completely defined. Due to the genetic predisposition of AD， the genetics and epigenetics studies have drawn much attention. Genetic research has identified multiple AD genetic susceptibility gene loci and related candidate genes. For example， the skin barrier dysfunction genes and Th2 immune genes were reported. These genetic studies are conducive to further clarifying the pathogenesis of AD and may provide new directions for the treatment of AD.

Key words: atopic dermatitis, genetics, innate immunity, ad-aptive immunity, skin barrier