中国实用儿科杂志 ›› 2023, Vol. 38 ›› Issue (9): 685-689.DOI: 10.19538/j.ek2023090607

• 专题笔谈 • 上一篇    下一篇

口服免疫耐受疗法干预合并食物过敏特应性皮炎的研究机制进展

  

  1. 苏州大学附属儿童医院, 江苏  苏州  215000
  • 出版日期:2023-09-06 发布日期:2023-09-22
  • 通讯作者: 钱华,电子信箱:qianhua721@163.com

Advances in the mechanism of oral tolerance induction for intervention combined with food allergy in atopic dermatitis 

  1. Children’s Hospital of Soochow University, Suzhou  215000,China
  • Online:2023-09-06 Published:2023-09-22

摘要: 特应性皮炎(atopic dermatitis, AD)是儿童常见的一种反复发作的、慢性、非感染性的炎症性皮肤病。AD与变应原致敏之间存在密切联系。口服耐受诱导疗法(oral tolerance induction,OTI)是通过主动抑制胃肠道对于抗原的特异性反应而建立免疫耐受的过程,目前已经被应用于干预多种特应性疾病,可能成为防治AD的新策略。

关键词: 特应性皮炎, 口服免疫耐受, Th2型免疫反应

Abstract: Atopic dermatitis is a recurrent, chronic and non-infectious inflammatory skin disease,which is common in children.AD has a close relationship with allergen sensitization. Oral tolerance induction therapy is an approach to establish immune tolerance by the active suppression of antigen-specific immune responses in the gastrointestinal tract. OTI has been used to intervene various atopic diseases, and may become a new strategy to prevent and treat AD.

Key words: atopic dermatitis, oral tolerance induction, Th2 immune response