中国实用儿科杂志

中国实用儿科杂志 ›› 2025, Vol. 40 ›› Issue (11): 952-957.DOI: 10.19538/j.ek2025110615

• 病例报告 • 上一篇    下一篇

儿童抗甘氨酸受体抗体阳性僵人综合征谱系疾病并舍格伦综合征1例

  

  1. 天津市儿童医院  天津大学儿童医院  天津市儿童出生缺陷防治重点实验室神经内科，天津  300203
  • 出版日期:2025-11-06 发布日期:2025-12-12
  • 通讯作者: 李东，电子信箱：lidongtjetyy@163.com
  • 基金资助:
    天津市医学重点学科建设资助项目［TJYXZDXK-3-016B］

A case of stiff person spectrum disorder in children with positive anti-glycine receptor （GlyR） antibodies combined with Sjogren’s syndrome and literature review

  1. Neurology Department，Tianjin Children’s Hospital（Children’s Hospital，Tianjin University），Tianjin Key Laboratory of Prevention and Treatment for Birth Defects，Tianjin  300203，China
  • Online:2025-11-06 Published:2025-12-12

摘要： 报告1例抗甘氨酸受体（GlyR）抗体阳性的僵人综合征谱系疾病合并舍格伦综合征患儿资料，结合文献分析该病临床特征及诊疗经验。患儿男，13岁，2024-12-04收治于天津市儿童医院，以间断发热及发作性身体僵硬为主要临床特征，脑脊液中抗GlyR1抗体阳性，且同时存在干眼等症状，结合特定抗体阳性及唇腺活检结果，考虑合并舍格伦综合征。两种疾病均具有特异性，且预后差，但由于临床罕见，容易误诊、漏诊，为患儿造成不良后果。因此儿童抗GlyR抗体阳性的僵人综合征谱系疾病合并舍格伦综合征应被临床医生广泛认识并提高关注度，改善患儿的长期预后。

关键词:

Abstract: The clinical data of a child with stiff person spectrum disorder with positive anti-glycine receptor（GlyR）antibodies combined with Sjogren’s syndrome are retrospectively analyzed，and relevant literature is reviewed to analyze the clinical characteristics and the diagnostic and therapeutic experience. The patient is a 13-year-old boy，admitted to Tianjn Children’s Hospital on December 4，2024，with intermittent fever and episodic physical stiffness as the main clinical features. The anti-GlyR1 antibody in the cerebrospinal fluid was positive，and there were also symptoms such as dry eye. Taking the positive specific antibody and lip gland biopsy results into account，it was considered to be complicated with Sjogren’s syndrome. Both diseases have specificity and poor prognosis，but due to their rarity in clinical practice，they are prone to misdiagnosis and missed diagnosis， leading to adverse results in the children. Therefore，the combination between stiff person spectrum disorder with positive anti-GlyR antibody and Sjogren’s syndrome in children should be widely aware of and paid great attention to by clinicians in order to improve the prognosis of the children.

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