中国实用儿科杂志

中国实用儿科杂志 ›› 2025, Vol. 40 ›› Issue (11): 937-940.DOI: 10.19538/j.ek2025110612

• 讲座 • 上一篇    下一篇

儿童金黄色葡萄球菌肺炎的抗感染治疗

  

  1. 1.昆明市儿童医院  昆明医科大学附属儿童医院 a 呼吸与危重症医学科，b 内镜综合科，云南  昆明  650034；2.云南省妇幼保健院儿科，云南  昆明  650051
  • 出版日期:2025-11-06 发布日期:2025-12-11
  • 通讯作者: 付红敏，电子信箱：fuhongmin@kmmu.edu.cn

Anti-infective treatment for Staphylococcus aureus pneumonia in children

  1. *Department of Pulmonary and Critical Care Medicine，Kunming Children’s Hospital & the Affiliated Children’s Hospital of Kunming Medical University，Kunming  650034，China
  • Online:2025-11-06 Published:2025-12-11

摘要： 金黄色葡萄球菌（Staphylococcus aureus，SA）肺炎是儿童常见且病死率较高的一种疾病。近年来，甲氧西林耐药金黄色葡萄球菌（MRSA）检出率增高，给临床的抗感染治疗带来严峻挑战。该文简要介绍了儿童SA肺炎的临床特征，致病特点与主要耐药机制，SA的抗菌药物及特点，并就甲氧西林敏感金黄色葡萄球菌（MSSA）肺炎、MRSA肺炎、万古霉素中介/耐药金黄色葡萄球菌（VISA/VRSA）肺炎的抗菌药物选择及治疗方案给予了推荐，并展望了未来SA的抗感染治疗与研究方向。

关键词:

Abstract: Staphylococcus aureus（SA）pneumonia is a common disease with a relatively high fatality among children. In recent years，the detection rate of methicillin-resistant SA（MRSA）is increased，posing severe challenges to the antibiotic therapy in clinical practice. This article briefly described the clinical characteristics of SA pneumonia in children，the pathogenicity，the main drug-resistant mechanisms of SA，and the anti-SA drugs and their characteristics. The antimicrobial agents and strategy for methicillin-sensitive Staphylococcus aureus（MSSA）pneumonia，MRSA pneumonia，and vancomycin-mediated/-resistant SA（VISA/VRSA）pneumonia were recommended.Also，the future anti-infective therapy and research direction were prospected.

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