关键词: 新型冠状病毒, 临床特征, 儿童, 合并感染, 基础疾病

Abstract: Objective    To study the clinical features of children with coronavirus disease. Methods    A retrospective analysis was performed on the medical data of 188 hospitalized children diagnosed with novel coronavirus infection in the First Affiliated Hospital of Xiamen University from December 2022 to March 2023. Divide them into mild group （34 cases）； moderate group （75 cases）， and severe or critical group （79 cases）； compare their clinical features，results of experimental examinations and outcomes. Results    The proportion of endocrine and nutritional metabolic disorders in the severe or critical group was higher than that in the mild group and the moderate group， the proportion of respiratory and nervous system disease was higher than that in the moderate group， the proportion of premature birth and dysplasia diseases was higher than that in the mild group， and the proportion of hematologic system diseases and immune  system diseases was lower than that in the mild group（P<0.05）. The fever peak washigher in severe or critical group， and the incidence of cough in moderate group was higher than that in mild group （P<0.05）. The white blood cell count was higher in severe or critical group than in mild group，C-reactive protein and procalcitonin were higher in severe or critical group than those in mild group and moderate group， and IL-6 was higher and the percentage of lymphocyte was lower than those in moderate group （P<0.05）. The rate of bacterial coinfection in severe or critical group was higher than that in mild group. Finally， three children died， while the rest were discharged after getting better. Conclusion    The increased proportion of children in severe condition or with basic diseases，complex coinfection and comorbidity pose greater challenges to disease diagnosis and treatment. The increase in white blood cell count， C-reactive protein， calcitonin and IL-6， and the decrease in lymphocyte ratio may indicate the aggravation of the disease. For children with respiratory and nervous system diseases， premature delivery and abnormal growth diseases and endocrine and nutritional metabolic disorders， it is necessary to be alert to the possibility of severe diseases. For children with other types of basic diseases， it is necessary to be alert to the impact of SARS CoV-2 infection on their basic diseases.

Key words: coronavirus disease 2019, clinical features, child, coinfection, basic diseases