中国实用儿科杂志

中国实用儿科杂志 ›› 2024, Vol. 39 ›› Issue (12): 934-940.DOI: 10.19538/j.ek2024120610

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婴幼儿感染呼吸道合胞病毒对未来呼吸健康的影响及公共卫生的挑战

  

  1. 广州医科大学附属第一医院  国家呼吸医学中心  呼吸疾病全国重点实验室  广州呼吸健康研究院  a 小儿呼吸科，b 肺功能检测中心，c 实验部病毒室，广东  广州  510000
  • 出版日期:2024-12-06 发布日期:2025-02-24
  • 通讯作者: 杨子峰，电子信箱：jeffyah@163.com

Impacts of respiratory syncytial virus infection in infants on future respiratory health and its challenges to public health

  1. *Department of Pediatric Pulmonology，First Affiliated Hospital of Guangzhou Medical University，National Clinical Research Center for Respiratory Disease，Sate Key Laboratory of Respiratory Disease，Guangzhou Institute of Respiratory Health，Guangzhou  510000，China
  • Online:2024-12-06 Published:2025-02-24

摘要： 呼吸道合胞病毒（respiratory syncytial virus，RSV）是全球5岁以下儿童急性下呼吸道感染（acute lower respiratory infection，ALRTI）的主要病原体之一。RSV感染所致ALRTI不仅可对婴幼儿造成严重的短期健康风险，还与未来哮喘和慢性阻塞性肺病的发生相关。文章全面阐述了RSV感染的流行病学特征、对儿童呼吸系统的长期影响以及相关机制，以期为更好地理解RSV感染带来的广泛健康影响、沉重的经济负担及对公共卫生系统构成的挑战，并制定积极有效的防控策略提供参考。

关键词: 呼吸道合胞病毒, 婴幼儿, 哮喘, 慢性阻塞性肺病, 经济负担

Abstract: Respiratory syncytial virus （RSV） is one of the leading pathogens responsible for acute lower respiratory infections （ALRTI） in children under five years old worldwide. ALRTI caused by RSV infection not only poses significant short-term health risks to infants but is also associated with the future development of asthma and chronic obstructive pulmonary disease. This review comprehensively discusses the epidemiological characteristics of RSV infection， its long-term impact on respiratory health， and the underlying mechanisms. It aims to provide insights into the broad health effects， substantial economic burden， and challenges to public health systems posed by RSV infection， thereby offering a reference for the development of proactive and effective prevention and control strategies.

Key words: respiratory syncytial virus, infants, asthma, chronic obstructive pulmonary disease, economic burden