Key points of preoperative evaluation of intrahepatic cholangiocarcinoma        ZENG Yong，HUANG Ji-wei. West China Hospital，Sichuan University，Chengdu 610041，China
Corresponding author：ZENG Yong，E-mail：zengyong@
medmail.com.cn
ZENG Yong and HUANG Ji-wei are the first authors who contributed equally to the article.
Abstract    Intrahepatic cholangiocarcinoma（ICC）is the second most common primary liver cancer with high malignancy and poor prognosis，and its incidence is gradually on the rise all over the world. Radical resection is currently the most effective treatment and may lead to a long-term survival.The low rate of radical resection and high rate of postoperative recurrence remain the greatest obstacles faced by both surgeons and ICC patients. Moreover，the high grade of malignancy with insidious onset results in some patients lost the opportunity of surgery at the initial diagnosis. Early screening，accurate clinical diagnosis，adequate preoperative evaluation and complete and accurate surgical programming are the guarantee for smooth implementation of surgery. Carcinoembryonic antigen (CEA) and CA19-9 are valuable in the diagnosis of ICC. Radiological techniques are critical for ICC diagnosis and assessment，of which ultrosonography is recommended the first line examination for early screening；whereas CT and MRI are the most useful modalities for comprehensive evaluation. Three-dimensional reconstruction provides more direct and accurate support for liver remnant assessment and surgery planning. It is still controversial for preoperative bile duct drainage. Estimated liver remnant and metastasis are two main concerns for a radical resection. Laparoscopic exploration，intraoperative ultrasonography and frozen pathological examination are three important modalities for an R0 resection evaluation.