目的:探讨125I粒子植入治疗进展期胃癌的初步方法和效果。方法:2004年3月至2005年10月，应用放射性125I粒子植入独立治疗9例不能切除的进展期胃癌。以CT下病变作为靶区参考，应用近距离治疗计划系统制定粒子分布、活度、数量，肿瘤周边剂量（110～130Gy）；采用开腹或经皮，单平面或双平面植入。术后观察血象、CT、生活质量（KPS）、疼痛缓解期、存活期。结果:生活质量评分(KPS)提高，7例疼痛缓解。急性上消化道放疗反应0～1级，无腹痛、呕血、肠梗阻等症状。结论:合理分布的125I粒子植入治疗进展期胃癌，对改善临床症状，提高生活质量有一定疗效，放射性损伤小，可作为不能手术切除进展期胃癌的重要补充治疗手段。

Objective:To discuss the clinical method and the effect of advanced gastric cancer following iodine125(125I) brachytherapy. Methods:From March 2004 to October 2005，125I radioactive seeds were applied to treat unresectable advanced gastric cancer.CT was chosen as target reference.Applying brachytherapy planning system decided iodine125 seeds’ distribution,activity and quantity.The matched peripheral dose（MPD）was 110～130Gy.Adopting intraoperative small incision or percutnaeous puncturation,iodine125 seeds were implanted with uniplane or biplane according to scheme.Postoperative hemogram,CT,KPS,pain relieving period and survival period were observed. Results:Patients’ appetite and KPS were improved.The pain relieving cases was 7 patients.0-1 degree acute radiotherapeutic sideeffects happened without other symptoms like abdominal pain,vomitus cruentus,intestinal obstruction etc. Conclusion:Applying 125I implantation to treat advanced gastric cancer with reasonable seeds distribution can improve clinic symptoms and their quality of life significantly.The radioactive damage is mild.The method can be used as an important supplementary treatment for unresectable advanced gastric cancer.