Abstract:

Sialic acid is a nine-carbon sugar acid，which is located at the terminal residue of glycoconjugations. The sialic acid-containing glycoconjugates are widely distributed on the surface of eukaryotic and prokaryotic cells and in serum and saliva. The sialic acid plays an important role in bacteria survival and pathogenesis. Some pathogenic bacteria coat themselves in sialic acid，providing resistance to components of host’s immune response，and some can use it as a nutrition. In this paper，the role of sialic acid and sialidase in bacteria survival and pathogen was reviewed.

Key words: sialic acid, sialidase, bacteria, survival, pathogenesis

摘要：

唾液酸是一种九碳糖酸，广泛存在于真核细胞和原核细胞细胞膜糖结合物的末端，在血清与唾液中普遍存在。研究表明，唾液酸与细菌营养、细菌细胞结构形成及细菌与细胞的相互作用等有关。文章着重对唾液酸及唾液酸酶在细菌生存和致病中的作用做一综述。

关键词: 唾液酸, 唾液酸酶, 细菌, 生存, 致病性