Abstract:

Periodontitis （PD） and inflammatory bowel disease （IBD） are both chronic inflammatory diseases. Their pathogenesis is mediated by a complex interplay between a dysbiotic microbiota and the host immune inflammatory response. Both have similar pathogenesis，in which one disease might alter the composition of the microbiota and increase the inflammatory response related to the other，resulting in a more severe condition of the other disease. This review reviews a research progress on the correlation between PD and IBD，aiming to explore the possible pathogenic interaction between PD and IBD，and point out the direction for future research studies.

Key words: periodontitis, inflammatory bowel disease, inflammation, dysbacteria

摘要：

牙周炎（periodontitis，PD）和炎症性肠病（inflammatory bowel disease，IBD）都是由宿主免疫炎症反应与菌群之间复杂的相互作用所介导的慢性炎症性疾病。两者具有相似的致病途径，其中一种疾病可能由于其导致的菌群失调及系统性炎症反应而诱发另一种疾病的产生或加重其严重程度。文章就PD与IBD的相关性研究进展做一综述，旨在探究两者相互影响的可能机制，并为未来PD与IBD双向关联研究指出方向。

关键词: 牙周炎, 炎症性肠病, 炎症, 菌群失调