Abstract:

Objective    To investigate the effect of tooth movement at different time after the repair of alveolar bone defects. Methods    Defective alveolar bone model was established on one side in forty white rabbits，which were filled with bone meal and attached with Bio-Gide membrane as experiment sides. The other side was performed routine tooth extraction as control. Track the mandibular second molar in both sides respectively in 1 week，1 month，2 months and 3 months after operation. One month later，the distance between the mandibular second molar and third molar was measured with electronic vernier caliper in the experiment side and control side. The mandibular tissue was made paraffin section and hematoxylin eosin staining. Three views of the periodontal ligament in a third place of the mesial roots of the second molar was randomly chosen to count the total number of osteoclasts. Paired-t test analysis was made to evaluate the displacement of the mandibular second molar in experiment and control side，and to evaluate the number of osteoclasts in two side. Results    In Group 1w and Group 1 m，the displacement of the mandibular second molar in experiment group was smaller than that in the control side（P＜0.05）. There was no statistical significance in Group 2 m and Group 3 m. The number of osteoclasts in the experiment side was less than the control group in Group 1 w and Group1 m（P＜0.05）. No statistical significance in Group 2 m and Group 3 m was found. Conclusion    Orthodontic treatment can be performed two months after the repair of alveolar bone defects.

Key words: alveolar bone defects, repair, orthodontic

摘要：

目的    探讨牙槽骨缺损修复后不同时机进行牙齿移动的时机。方法    本研究于2013年9月至2014年3月在福建医科大学实验动物中心和福建医科大学口腔医学院完成。选择40只大白兔，建立一侧下颌牙槽骨缺损模型，植入骨粉，置Bio-Gide膜，另一侧正常拔牙对照。分别于术后1周和1、2、3个月牵引两侧下颌第二磨牙近中。加力1个月后，取实验侧和对照侧下颌骨组织块，电子游标卡尺测量下颌第二磨牙与第三磨牙之间的距离；组织块制作石蜡切片，进行常规苏木精-伊红染色，选取第二磨牙牙根根中1/3处牙周膜，每个部位随机选择3个视野计数破骨细胞数目总和。1周组、1个月组、2个月组、3个月组的实验侧与对照侧的下颌第二磨牙移动距离、同一时间点压力区的破骨细胞数均行配对t检验分析。结果    1周组、1个月组实验侧下颌第二磨牙移动距离小于对照侧，压力区破骨细胞少于对照侧，差异均有统计学意义（均P＜0.05）；而2个月组、3个月组差异均无统计学意义（均P＞0.05）。结论    牙槽骨缺损修复2个月后适合进行正畸牙移动。

关键词: 牙槽骨缺损, 修复, 正畸