Abstract: Periodontitis is a chronic multi-factor inflammatory disease caused by bacterial plaque，which causes local and systemic inflammatory response. Atherosclerosis is the pathological basis of many cardiovascular diseases. Its occurrence and development are closely related to oxidative stress，inflammation and dyslipidemia. In recent years，a large number of studies have elucidated the correlation between the two in mechanism of action，animal experiments and clinical cases，and periodontitis is an independent risk factor for atherosclerosis. However，because of the multifaceted and long-term nature of the two diseases，it is difficult to establish a clear cause-and-effect relationship. In this paper，the research progress in the correlation between periodontitis and atherosclerosis is reviewed.

Key words: periodontitis, cardiovascular disease, atherosclerosis, periodontal pathogen

摘要： 牙周炎是菌斑微生物引起的慢性多因子炎症性疾病，其造成了局部和全身的炎症反应。动脉粥样硬化是心血管疾病的病理基础，其发生发展与氧化应激、炎症和血脂紊乱均密切相关。近年来大量研究在作用机制、动物实验和临床病例中阐释了二者的相关性，且牙周炎是动脉粥样硬化的独立危险因素。但因两种疾病的多方面和长期性使得很难建立明确的因果关系，文章重点综述近年来牙周炎与动脉粥样硬化相关性的研究进展。

关键词: 牙周炎, 心血管疾病, 动脉粥样硬化, 牙周致病菌