Abstract:

Wnt5a is a representative noncanonical Wnt molecule and the nocanonical Wnt signalling pathway induced by it regulates a variety of cellular functions，such as proliferation，differentiation，migration， adhesion and polarity. Recent studies have shown that Wnt5a and its signaling pathways play a pivotal role in the regulation of dental mesenchymal stem cells（DMSCs）， whose mechanism has become a hot topic for tooth tissue engineering，providing a new way of thinking for dental tissue regeneration. In this paper，the new researches on Wnt5a and its mediated signaling pathways in terms of dental stem cells were overviewed.

Key words: Wnt5a, Wnt noncanonical signaling pathway, dental stem cells, osteogenesis

摘要：

Wnt5a是非经典Wnt蛋白中具有代表性的蛋白，其介导的非经典Wnt信号具有调控细胞增殖、分化、迁移和极化的作用。近年来研究发现，Wnt5a及其介导的信号通路在调控牙源性干细胞方面起重要作用，其机制成为牙组织工程学研究热点，也为牙再生提供了新的思路。以下仅对Wnt5a及其介导的信号通路在牙源性干细胞方面的研究进展做一综述。

关键词: wnt5a, 非经典Wnt信号通路, 牙源性干细胞, 成骨分化