Abstract: Objective    To study in vivo osteogenic properties of calcium silicophosphate（CPS） by using the tooth extraction socket model of SD rats. Methods    Select 45 SD rats at 6 weeks of age. According to the dental extraction socket filling materials，they were randomly divided into 3 groups，each with 15 rats. CPS group：two molars of the right upper jaw were extracted under general anesthesia，and CPS bone powder was placed in the extraction socket，and the extraction socket was covered with Bio-Gide membrane and sutured. Bio-Oss group：Bio-Oss bone powder was placed in the extraction socket and the extraction socket was covered with Bio-Gide membrane and sutured. Control group：no filling material was placed after tooth extraction and the extraction socket was covered with Bio-Gide membrane and sutured. The rats were sacrificed at 2，4，and 8 weeks after the tooth extraction，and the maxilla was obtained. Imaging and histobiological methods were used to measure and evaluate the healing of the tooth extraction socket. Results　The bone volume fraction, bone density and thickness of trabecular bone at the extraction site of all rat samples at 2，4，and 8 weeks after extraction increased with the increase of the time after extraction. At 4 weeks，the bone volume fraction and bone trabecular thickness of the extraction site in the Bio-Oss group were greater than those in the CPS group and the control group（P < 0.05）. At 8 weeks，the bone volume fraction，alveolar bone width，alveolar bone height and bone density of the CPS group were slightly higher than those of the Bio-Oss group and the control group. The bone trabecular thickness of the CPS group was between Bio-Oss group and the control group，but there were no statistically significant differences in the indicators among the 3 groups（P > 0.05）. Histobiological results showed that only a small amount of undegraded material was seen in CPS group and Bio-Oss group at 8 weeks after the operation；there were more new bone formation around，and the bone was denser. Conclusion    CPS has good osteogenic properties and degradation performance in the body，can effectively reduce alveolar bone atrophy after tooth extraction，and has the potential to be used as a filling material for extraction site preservation.

Key words: calcium silicophosphate, site preservation, osteogenesis, alveolar bone

摘要： 目的    通过SD大鼠拔牙窝模型研究硅磷酸钙（CPS）骨粉的体内成骨性能。方法    选择45只6周龄SD大鼠，全麻下拔除右侧上颌2颗磨牙后按照拔牙窝充填材料随机分为3组，每组15只。CPS组：拔牙后于拔牙窝内放入CPS骨粉，用Bio-Gide膜覆盖拔牙窝并缝合；Bio-Oss组：拔牙后于拔牙窝内放入Bio-Oss骨粉，用Bio-Gide膜覆盖拔牙窝并缝合；对照组：拔牙后不放置充填材料，直接用Bio-Gide膜覆盖拔牙窝并缝合。于术后2、4、8周分别处死每组大鼠5只并取材上颌骨，采用影像学和组织学检测方法测量并评价拔牙窝牙槽骨愈合情况。结果  所有大鼠样本在术后2、4、8周这3个时间点的拔牙位点骨体积分数、骨密度及骨小梁厚度均随着术后时间延长而增大。术后4周时，Bio-Oss组拔牙位点骨体积分数、骨小梁厚度大于CPS组和对照组（P < 0.05）。术后8周时，CPS组的拔牙位点骨体积分数、牙槽骨宽度、牙槽骨高度及骨密度略高于Bio-Oss组和对照组， CPS组的骨小梁厚度介于Bio-Oss组和对照组之间，但3组间各指标的差异均无统计学意义（均P > 0.05）。组织学观察发现，术后8周CPS组和Bio-Oss组仅可见少量的未降解材料，周围有较多新骨形成，骨质较致密。结论    CPS在体内具有良好的促成骨能力和降解性能，可有效减少拔牙后牙槽骨萎缩，具有作为位点保存充填材料的潜力。

关键词: 硅磷酸钙, 位点保存, 成骨, 牙槽骨