Abstract:

Objective    To study the impact of simvastatin on peri-implantitis osseointegration. Methods    Select 4 adult dogs and extract bilateral premolars 1， 2 and 3 under general anesthesia； 24 implants was performed immediately in each dog； 12 weeks after surgery，silk knot was used to establish the peri-implantitis model，and they were randomly divided and treated with: （1）simple removal  of inflammatory  tissue around implant （blank group）； （2）debridement plus absorbable membrane associated with bone graft and local injection of simvastatin（3.0 mg/kg·d）（experiment group）；（3）debridement plus absorbable membrane associated with bone graft and local injection of blank solvent （control group）. They were killed after 16 weeks. Naked eye and Scanning electron microscopy was used to observe and measure bone reconstruction of defect location. Results    There was  significant difference in the expressions of  bone density and bone strength between experiment group and control group（P＜0.05）. Conclusions    Simvastatin can improve bone formation.

Key words: peri-implantitis, simvastatin, GBR

摘要：

目的    探讨辛伐他汀在种植体周围炎骨缺损区应用对种植体骨再结合的影响。方法    本研究于2011年6月至2012年2月在哈尔滨医科大学动物实验中心完成。选取4只成年杂种犬，全麻下拔除双侧第一、二、三前磨牙，即刻植入种植体24颗，植入12周确定骨结合后，丝线栓结法建立实验性动物口腔种植体周围炎模型。随机进行分组治疗。（1）空白组（6颗种植体）：单纯去除种植体周围炎性肉芽组织，骨缺损区不填入任何材料；（2）实验组（9颗种植体）：去除种植体周围炎性肉芽组织，骨缺损区填入骨粉+生物膜+局部注射辛伐他汀（3.0 mg/kg·d）；（3）对照组（9颗种植体）：去除种植体周围炎性肉芽组织，骨缺损周围填入骨粉+生物膜+局部注射等量空白溶剂。3组术后龈缘内均应用盐酸米诺环素软膏2周（1次/周），实验组和对照组局部注射5 d（1次/d）。术后16周处死动物，行大体观察、缺损区重建骨量测量、电镜观测。结果    局部注射辛伐他汀实验组骨重建区骨密度较对照组高，实验组骨重建区骨再结合强度较对照组高，差异有统计学意义（P＜0.05）。结论    局部注射辛伐他汀可促进骨生长。

关键词: 种植体周围炎, 辛伐他汀, 引导骨再生