Abstract:

Objective　To analyse clinical features of attention deficit hperactivity disorder（ADHD） and its relationships with factors related to epilepsy. Methods　The clinical data of 180 children diagnosed with epilepsy in Pediatric Neurology Department of Shengjing Hospital between September 2015 and February 2016 were obtained and analyzed. 125 healthy children in the same district served as control. Results　The morbidity of attention deficit hyperactivity disorder in children with epilepsy was 28.89%. The morbidity was 7.2% in the controls. The difference was statistically significant （P＜0.05）. Among the risk factors of epilepsy， the gender，seizure times and a single oral AEDS had no effect on the morbidity of ADHD. The morbidity was connected with an earlier onset age，GTCS，an unrecovered EEG and multiple AEDS of epilepsy. The difference was statistically significant （P＜0.05）. The children with epilepsy had a higher score by the evaluation of Conners Scale. The behavior，study and the impulsive-hyperactive behavior problems were more obvious among epilepsy children with attention deficit hyperactivity disorder（P＜0.05）. Conclusion　The incidence of ADHD is high in children with epilepsy，and the initial onset age of epilepsy，the unrecovered EEG and various antiepileptic drugs are closely related with the prevalence of ADHD in children with epilepsy. In children with epilepsy and ADHD，the behavior problems，learning problems and hyperactivity-impulsive aspects are more significant.

Key words: child, epilepsy, ADHD, comorbidity disease

摘要：

目的    探讨癫痫儿童注意缺陷多动障碍（ADHD）的临床特点，分析癫痫相关因素与ADHD之间的关系。方法　选取2015-09-01—2016-02-01就诊于中国医科大学附属盛京医院小儿神经科癫痫专业门诊的180例患儿为研究组，选择辽宁地区2所公立小学和1所公立初中的125例既往健康儿童作为对照组，详细收集基本资料并完成相关问卷调查和心理量表评估。结果　癫痫儿童ADHD共患率为28.89%，而对照组ADHD的发生率为7.2%，差异有统计学意义（P＜0.05）。癫痫相关因素中：性别、癫痫发作次数、口服单一抗癫痫药对共患ADHD无影响，而与癫痫首发年龄、发作是否控制、脑电图是否恢复正常、联合口服多种抗癫痫药物存在明显关联，差异有统计学意义（P＜0.05）。癫痫儿童的Conners行为评分普遍较高，品行问题、学习问题、多动和冲动等问题较单纯癫痫患儿显著，差异有统计学意义（P＜0.05）。结论　癫痫患儿中，ADHD发生率较高，癫痫首发年龄、是否控制、脑电图是否恢复正常、联合口服多种抗癫痫药物与癫痫儿童共患ADHD密切相关。癫痫儿童共患ADHD的品行问题、学习问题、多动-冲动方面表现较显著。

关键词: 儿童, 癫痫, 注意缺陷多动障碍, 共患病