Abstract:

The coronary artery lesions（CAL），especially coronary artery aneurysm，is the most serious complication of Kawasaki disease（KD）. In order to predict the possible risk and reduce the incidence of CAL，the articale reviewed the relationship between some clinical indexes and the incidence of CAL，such as age and gender，duration of fever，C-reactive protein，NT-proBNP，peripheral blood leukocyte count，erythrocyte sedimentation rate，serum albumin level，application time and dose of IVIG and recurrent KD. It also introduced the application of Harada score and Kobayashi score to assess the risk of CAL. Some new potential biomarkers for the diagnosis of KD with CAL were also introduced.

Key words: Kawasaki disease, coronary artery lesions, child

摘要：

冠状动脉损害（CAL）、尤其是冠状动脉瘤是川崎病最严重的并发症。为了预测可能发生CAL的风险，尽早采取措施，使CAL发生率和损伤最大程度减小，文章逐一评述了年龄和性别、发热持续时间、C反应蛋白、血浆N-端脑钠肽前体（NT-proBNP）、外周血白细胞计数、红细胞沉降率、血浆白蛋白水平、静脉注射丙种球蛋白（IVIG）的时间和剂量、难治性川崎病复发等单一临床特征及实验室指标与CAL发生率的关系。还介绍了原田评分、小林评分评价系统评估CAL风险的应用价值。此外，腱糖蛋白 C （TN-C）、microRNAs （miRNAs）、基因多态性等实验室指标也在文中有所介绍。

关键词: 川崎病, 冠状动脉损害, 儿童