Abstract:

Objective    To investigate the distribution and antimicrobial resistance of enterococci isolated from urine
in children. Methods    The clinical data and drug sensitivity test of pediatric patients who had enterococci isolated from midstream urine in Guangzhou Women and Children’s Medical Center from January 2011 to December 2014 were analyzed. Results    Totally 82 enterococcal isolated were detected；E.faeium accounted for 64.6%（53 strains），and E.faecalis accounted for 35.4%（29 strains）. E.faeium was susceptible to tigecycline，vancomycin，quinupristin and dalfopristin，and linezolid. E.faecalis was susceptible to tigecycline，vancomycin，nitrofrantoin，linezolid，quinolones and penicillin. The prevalence of vancomycin-resistant E.faeium and E.faecalis was 1.9%and 3.4%，respectively. Conclusion    The main enterococci isolated from urine are E.faeium.Different kinds of enterococci have different clinnical characteristics. Enterococci are still highly susceptible to vancomycin. Clinical pediatricians should pay attention to the opportunistic pathogenicity of enterococci.

Key words:  , enterococci；urinary tract infection；antimicrobial resistance；children

摘要：

目的    了解儿童泌尿系统肠球菌的分布特点及对药物的敏感性， 指导临床合理用药。方法    分析广州市妇女儿童医疗中心儿童院区肾内科2011年1月至2014年12月中段尿培养肠球菌阳性患儿的临床资料及药敏试验结果。结果    82株肠球菌属中屎肠球菌53株，占64.6%，粪肠球菌29株，占35.4%。屎肠球菌对替加环素、万古霉素、喹奴普汀/达福普汀、利奈唑胺敏感，粪肠球菌对替加环素、万古霉素，呋喃妥因、利奈唑胺、喹诺酮类及青霉素类敏感。万古霉素耐药的屎肠球菌和粪肠球菌的检出率分别为1.9%和3.4%。结论    纳入儿童中段尿培养分离的肠球菌以屎肠球菌为主；不同种属的肠球菌有不同的临床特点；肠球菌对万古霉素有较好的敏感性；应注意其条件致病菌的特点。

关键词: 肠球菌, 泌尿系感染, 耐药性, 儿童