Abstract:

Abstract：Objective　To study the characteristics and differences of serum bone alkaline phosphatase（BAP）， carboxyterminal propeptide of type Ⅰ procollagen （PICP） and osteocalcin（OC） in female adolescents. Methods　A total of 1093 healthy Tibetan-Han adolescents living in Lhasa， Naqu and Jinzhou aged 12～< 19 years were selected，whose height and the levels of BAP， PICP and OC were tested. Results　The levels of BAP， PICP and OC in Lhasa and Naqu were higher than those in Jinzhou. The difference was statistically significant in Lhasa and Jinzhou（ P < 0.01）.The values of serum BAP， PICP and OC reached the peak at 12～< 13 years in all groups. Levels of markers declined with increase of age after peak （P < 0.05）， but decreasing trend was flat in Jinzhou. Positive correlativity was observed between BAP， PICP，OC and height（r = 0.56， 0.48， 0.43，P < 0.01）. Conclusion　Change characteristics of serum BAP，PICP and OC is consistent with age in female adolescent in different altitude area， but the levels are higher in Tibetan Plateau than that  in Han Plain. This reveals that in Tibetan Plateau the normal reference values should be established for the bone biomarkers. We should further improve the living conditions of Plateau girls so as to promote its growth potentiality.

Key words: bone alkaline phosphatase, carboxyterminal propeptide of typeⅠprocollagen, osteocalcin, adolescent

摘要：

探讨不同海拔地区女性青少年血清骨碱性磷酸酶（BAP）、Ⅰ型前胶原羧基端前肽 （PICP）和骨钙素（OC）的特点及其差异，为临床运用提供基础数据。方法　2003年6月至2005年10月采用分层整群抽样方法，从西藏拉萨（海拔3500 m）、西藏那曲（海拔4500m）和辽宁锦州（海拔28 m）的大、中、小学随机抽取12～ < 19岁健康女性青少年共1093名，进行身高及血清BAP、PICP和OC测定。结果　拉萨组和那曲组血清BAP、PICP和OC总体水平均高于锦州组，组间差异有统计学意义（P < 0.01）；拉萨组3个生化标志物显著高于那曲组（P < 0.01或P < 0.05）。3组血清BAP、PICP和OC均在12～ < 13岁时出现高峰，且随年龄增长迅速下降，但锦州组3个生化标志物随年龄变化趋势较拉萨组和那曲组平缓。血清BAP、PICP和OC水平均与身高密切相关（r = 0.56、0.48、0.43，P < 0.01）。 结论　不同海拔女性青少年血清BAP、PICP和OC随年龄变化特点基本一致，但高原藏族青少年血清BAP、PICP和OC高于平原汉族青少年。应建立针对高原藏族青少年的骨形成标志物的正常参考值。

关键词: 骨碱性磷酸酶, Ⅰ型前胶原羧基端前肽, 骨钙素, 青少年