Abstract:

Objective　To observe the clinical efficacy of Huaiqihuang in the treatment of children with bronchial asthma and its effects on the level of cytokines Th1，Th2 and PON1. Methods　A total of 180 children with bronchial asthma admitted between June 2014 and June 2015 in the Fourth Hospital of Baotou were randomized into the observation group（96 cases of GINA regimen treatment combined with Huaiqihuang）and the GINA regimen treatment group（84 cases），healthy children were enrolled as control group（50 cases）. Times of respiratory tract infection occurrence, asthmatic attacks, application of emergency medicine, hospitalization due to asthmatic and the levels of IL-4，IL-12，IL-13，INF-γ and PON1 were observed before and after treatment. Results　There were significant differences about the times of upper respiratory tract infections, bronchitis and pneumonia, asthma attacks, application of emergency medicine and hospitalization due to asthmatic（P＜0.05）. There were significant differences about the changes of IL-4, IL-12, IL-13, INF-γ and PON1 before and after treatment（P＜0.01）. Conclusion　The treatment of bronchial asthma in children with Huaiqihuang granule can reduce the incidence of respiratory infections and the number of asthmatic attacks and improve clinical effect. The Huaiqihuang granule alleviating asthma symptoms may by decreasing the levels of Th2 cytokines（IL-4，IL-13）and also by increasing the levels of Th1 cytokines（IL-12, IFN-γ）and PON1.

Key words: Huaiqihuang granule, bronchial asthma, child, paraoxonase 1

摘要：

目的　研究槐杞黄颗粒对哮喘患儿的辅助治疗作用，以及其对外周血中Th1、Th2相关细胞因子、对氧磷酶1（PON1）水平的影响。方法　将2014年6月至2015年6月内蒙古自治区包头市第四医院收治的符合哮喘诊断标准的180例患儿随机分为研究组（96例）和常规组（84例），设定正常对照组（50例）。两组哮喘患儿均给予规范化哮喘基础治疗，研究组同时给予槐杞黄治疗3个月。比较两组哮喘患儿治疗前1个月、治疗后第1个月、第3个月及第6个月呼吸道感染次数、喘息发作次数、应用急救药物次数、因喘息住院次数，并比较治疗前及治疗后3个月的相关细胞因子水平变化。结果　治疗后，上呼吸道感染次数、支气管炎和肺炎、喘息发作次数、应用急救药物次数和因喘息住院次数较治疗前均明显减少（P＜0.05）。治疗前、后白介素-4（IL-4）、白介素-13（IL-13）、白介素-12（IL-12）、干扰素-γ（IFN-γ）和PON1水平变化差异均有统计学意义（P＜0.01）。结论　槐杞黄颗粒辅助治疗哮喘，能够减少呼吸道感染及喘息发作的次数，帮助提高临床治疗效果；可能通过降低外周血中Th2相关细胞因子（IL-4、IL-13）水平，提高Th1相关细胞因子（IL-12、IFN-γ）以及PON1水平，发挥治疗哮喘的作用。

关键词: 槐杞黄颗粒, 支气管哮喘, 儿童, 对氧磷酶1