中国实用儿科杂志

中国实用儿科杂志 ›› 2021, Vol. 36 ›› Issue (9): 665-672.DOI: 10.19538/j.ek2021090606

• 党为人民谋健康的 100 年·专题笔谈 • 上一篇    下一篇

特应性进程的机制及治疗进展

  

  1. 重庆医科大学附属儿童医院皮肤科  国家儿童健康与疾病临床医学研究中心  儿童发育疾病研究教育部重点实验室  儿童感染免疫重庆市重点实验室，重庆  400014
  • 出版日期:2021-09-06 发布日期:2021-12-02
  • 通讯作者: 罗晓燕，电子信箱：luoxycq@hotmail.com
  • 基金资助:
    重庆市卫健委中青年医学高端人才项目（2019GDRC010）

Mechanism of atopic march and the treatment progress

  1. Department of Dermatology，Children’s Hospital of Chongqing Medical University；National Clinical Research Center for Child Health and Disorders；Ministry of Education Key Laboratory of Child Development and Disorders；Chongqing Key Laboratory of Child Infection and Immunity，Chongqing  400014，China
  • Online:2021-09-06 Published:2021-12-02

摘要： 过敏性疾病的发生按照特定时间顺序进行，由婴儿期特应性皮炎和食物过敏进展为儿童及成人期哮喘和过敏性鼻炎的现象称为特应性进程。其发生与生命早期环境、母体过敏、遗传、免疫、皮肤屏障缺陷、微生物菌群等密切相关。饮食、环境干预、特异性免疫治疗及新近出现的靶向辅助型T细胞2（Th2）所介导炎症的生物制剂等，为特应性进程的干预治疗提供了崭新的方向。

关键词: 特应性进程, 过敏性疾病, 发病机制, 治疗

Abstract: The development of allergic diseases follows a specific temporal order. Atopic march is considered as a tendency to develop from atopic dermatitis and food allergy in infancy to asthma and allergic rhinitis in school-age children. It is caused by a complex combination of perinatal factors，maternal allergy, genetic predisposition，immune dysregulation，skin barrier defects and microbiota. Dietary，environmental intervention, antigen-specific immunotherapy，and the newly emerging Th2-targeting therapies provide new directions for the intervention treatment of atopic march. 

Key words: atopic march, allergic disease, pathogenesis, treatment