中国实用儿科杂志

中国实用儿科杂志

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加强对儿童食物过敏相关胃肠道疾病的认识

  

  1. 浙江大学医学院附属儿童医院消化科  国家儿童健康与疾病临床医学研究中心  国家儿童区域医疗中心， 浙江  杭州  310052
  • 出版日期:2021-04-06 发布日期:2021-05-06

Strengthen the understanding of food allergy-related gastrointestinal diseases in children

  1. Department of Gastroenterology，the Children’s Hospital，Zhejiang University School of Medicine；National Clinical Research Center for Child Health；National Children’s Regional Medical Center，Hangzhou  310052，China
  • Online:2021-04-06 Published:2021-05-06

摘要： 食物过敏是儿童常见疾病，可累及多个系统。如果引起消化道黏膜损伤，以消化道症状为主要表现的一类疾病称为食物过敏相关胃肠道疾病，以非IgE介导为主，也可经IgE介导或IgE和非IgE混合介导。食物过敏相关胃肠道疾病的临床表现大多非特异性，诊断有赖于食物回避+激发试验。治疗原则主要包括治疗食物过敏引起的急性全身反应、回避食物过敏原及营养治疗、变应原治疗和长期管理。同时初步提出了该领域的主要研究方向。

关键词: 食物过敏, 食物过敏相关胃肠道疾病, 诊断, 治疗, 儿童

Abstract: Food allergy is a common disease in children，which can involve multiple systems. If it causes gastrointestinal mucosal damage，then a kind of disease with gastrointestinal symptoms as the main manifestation is called food allergy-related gastrointestinal disease，which is mainly mediated by non-IgE，and may also be mediated by IgE or mixed IgE and non-IgE. Most of the clinical manifestations of food allergy-related gastrointestinal diseases are nonspecific，and the diagnosis depends on food avoidance and provocation test. The treatment principles mainly include the treatment for acute systemic reaction caused by food allergy，avoidance of food allergens and nutritional treatment，allergen treatment and long-term management. At the same time，the future research direction in this field is suggested.

Key words: food allergy, food allergy-related gastrointestinal disease, diagnosis, treatment, child