关键词: 肝细胞癌, 肝动脉灌注化疗, 分子靶向治疗, 免疫治疗

Abstract: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors, which seriously threatens the health and quality of life of Chinese people. Systematic therapy represented by targeted and immunotherapy is the standard treatment for advanced HCC, but the overall effective rate is not high. Hepatic arterial infusion chemotherapy (HAIC) can effectively control intrahepatic tumors, with the advantages of minimally invasiveness and good safety. Systemic therapy combined with HAIC can effectively improve the objective remission rate and disease control rate, and improve the quality of life. Currently, there are reports on the positive application of HAIC in the downgrading before surgery, adjuvant treatment after surgery, and comprehensive treatment. However, how to screen out the advantageous population at the initial diagnosis of patients and achieve individualized medication according to the characteristics of patients’ condition still needs to be further explored.

Key words: hepatocellular carcinoma, hepatic artery infusion chemotherapy, molecular targeted therapy, immunotherapy