关键词: 胰腺癌, 胰十二指肠切除术, 新辅助治疗, 免疫治疗, 分子分型

Abstract: From technology to strategy-focus on hot issues of pancreatic cancer treatment in 2023        LIU Guang-nian, TIAN Xiao-dong, YANG Yin-mo. Department of Hepatobiliary and Pancreatic Surgery，Peking University First Hospital，Beijing 100034，China
Corresponding author：YANG Yin-mo,E-mail:yangyinmo@263.net
Abstract    Pancreatic cancer has the worst prognosis among all gastrointestinal tumors.The development of multidisciplinary comprehensive diagnostic and treatment models for pancreatic cancer in the context of systemic therapy has had a profound impact on pancreatic surgery.Significant progress has been made in surgical techniques，with notable improvements in surgical safety and resection rates.Minimally invasive surgery is gradually becoming the future trend in pancreatic surgery.Neoadjuvant therapy is becoming increasingly popular and standardized，and are now the standard treatment modalities for patients with borderline resectable and locally advanced pancreatic cancer.The dawn of immune and targeted therapies is emerging，yet sensitive targets are still lacking，characterizing pancreatic cancer as an“immune-cold tumor.”There is an urgent need for breakthroughs and translation in basic research on pancreatic cancer.A deeper understanding of its biology and accurate oncological evaluations are fundamental in guiding clinical decisions and improving long-term prognosis for patients with pancreatic cancer.

Key words: pancreatic cancer, pancreaticoduodenectomy, neoadjuvant therapy, immunotherapy, molecular classification