关键词: 精准医学, 胰腺癌, 新辅助治疗, 辅助治疗

Abstract: Application of precision medicine in neoadjuvant therapy and adjuvant therapy of pancreatic cancer        XU Hua-xiang, LIU Liang. Department of Pancreatic Surgery & Cancer Center, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Corresponding author: LIU Liang, E-mail: liu.liang@zs-hospital.sh.cn
Abstract    Low surgical resection rate and high postoperative recurrence and metastasis rate are the main factors affecting the long-term survival of pancreatic cancer patients. Neoadjuvant therapy and adjuvant therapy are important strategies to improve surgical resection rates, reduce postoperative recurrence and prolong the survival time of patients. In recent years， with the development of high-throughput sequencing methods such as gene sequencing and multi-omics studies, precision medicine has greatly progressed in treating pancreatic cancer. Through many aspects, such as the mining of key therapeutic targets, the screening of suitable populations, the sensitivity and side effects of therapies, and the dynamic monitoring of treatment, precision medicine could improve the efficacy of neoadjuvant therapy and adjuvant therapy for pancreatic cancer and prolong the postoperative survival time of patients.

Key words: precision medicine, pancreatic cancer, neoadjuvant therapy, adjuvant therapy