关键词: 肝胆肿瘤, 新辅助治疗, 免疫治疗, 靶向治疗, 疗效标记物

Abstract: Exploration and evaluation of predictors of efficacy in neoadjuvant therapy for hepatobiliary neoplasms                       GAO Qiang, LIU Yu-ming. Zhongshan Hospital Affiliated to Fudan University, Fudan University Liver Cancer Institute, Shanghai 200032, China
Corresponding author: GAO Qiang, E-mail:gao.qiang@zs-hospital.sh.cn
Abstract    Hepatobiliary cancers seriously threaten the health of our people due to their high morbidity, recurrence rate and mortality. Advances in primary prevention, early screening and early diagnosis, drug therapy, and systemic treatment are expected to change this situation. Neoadjuvant targeted therapy and immunotherapy have received widespread attention as one of the promising ways to improve the efficacy of surgical treatment. However, its promotion and application are limited due to unsatisfactory response efficiency and the occurrence of adverse events. Therefore, it is urgent to find effective biomarkers to screen out potential benefit groups and reduce the incidence of adverse events. In hepatobiliary cancers, the research on biomarkers to predict the efficacy of neoadjuvant target immunotherapy is still in its infancy, while some research results have been obtained in other types of cancers and advanced hepatobiliary cancers. Integrating multi-scale markers is a future direction for the prediction of neoadjuvant efficacy in hepatobiliary tumors.

Key words: hepatobiliary cancers, neoadjuvant therapy, targeted therapy, immunotherapy, biomarkers for treatment efficiency