关键词: 局部进展期胃癌, 免疫治疗, 免疫检查点抑制剂, 新辅助治疗

Abstract: Research progress of immune checkpoint inhibitors in neoadjuvant therapy of locally advanced gastric cancer              ZHAO Xue-song*, GAO Zhi-dong，ZHOU Jing, et al.*Department of Gastroenterological Surgery, Peking University People′s Hospital, Beijing 100044, China
Corresponding author：YE Ying-jiang，E-mail:yeyingjiang@
pkuph.edu.cn
Abstract    Immune checkpoint inhibitors（ICIs）continue to advance in gastric cancer，which bringing new options for the neoadjuvant treatment.Throughout the current research on neoadjuvant immunotherapy for locally advanced gastric cancer，ICIs in combination with chemotherapy/radiotherapy neoadjuvant therapy have shown good therapeutic efficacy and may further enhance the efficacy on the existing basis. For specific populations，immunotherapy combined with targeted therapy or dual-immune neoadjuvant therapy may show advantages.Due to immune-related toxicity，the use of immune checkpoint inhibitors should be cautious，and it remains a great challenge to screen the beneficiaries of immunotherapy and select the best treatment options.It is expected that the subsequent phase Ⅲ clinical studies will reveal the true effect of ICIs in neoadjuvant treatment of gastric cancer，leading to a new breakthrough in immunotherapy in gastric cancer and further improving the survival of gastric cancer patients.

Key words: locally advanced gastric cancer, immunotherapy, immune checkpoint inhibitors, neoadjuvant therapy