中国实用外科杂志

中国实用外科杂志 ›› 2011, Vol. 31 ›› Issue (03): 198-202.

• 专题笔谈 • 上一篇    下一篇

胆囊癌癌前病变的新认识与处理原则

赵    刚，吴志勇   

  1. 上海交通大学医学院附属仁济医院普通外科，上海200127
  • 出版日期:2011-03-01 发布日期:2011-05-30

  • Online:2011-03-01 Published:2011-05-30

PDF

摘要：

原发性胆囊癌作为最常见的胆道恶性肿瘤，恶性程度较高，术前明确诊断率低，临床上确诊时大多属中晚期，总体预后较差。胆囊癌病因迄今未明确，胆囊黏膜的不典型增生和胆囊腺瘤是目前公认的胆囊癌癌前病变。而部分胆囊炎、胆囊结石、胆囊息肉样病变以及先天性胰胆管合流异常等胆囊良性疾病可能通过一定的病理生理过程而逐渐演变成胆囊癌癌前病变，进而发展成为胆囊癌。因此，重视胆囊癌癌前病变，把握合理的手术时机，以提高胆囊癌的存活率。

关键词: 胆囊癌, 癌前病变

Abstract:

New understanding and treatment principle of precancerosis of gallbladder carcinoma        ZHAO Gang, WU Zhi-yong. Department of General Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China
Corresponding author: WU Zhi-yong, E-mail:zhiyongwu@gmail.com
Abstract    Gallbladder carcinoma is the most common carcinoma of biliary tract and has high degree of malignancy. Most of the clinical diagnosis is in the late stage, because gallbladder carcinoma has low rate of preoperative diagnosis. The overall prognosis is poor. Now the cause is not clear. Dysplasia of gallbladder mucosa and gallbladder adenoma are recognized as precancerosis of gallbladder carcinoma. And some benign gallbladder diseases such as cholecystitis, gallstones, polypoid lesions of the gallbladder and anomalous junction of the pancreaticobiliary duct gradually may evolve into precancerosis of gallbladder carcinoma by the process of pathophysiology，then develop into gallbladder carcinoma. Therefore, It should pay more attention to precancerosis of gallbladder carcinoma and choose a reasonable time of surgery to improve the survival rate.

Key words: gallbladder carcinoma, precancerosis