中国实用外科杂志

中国实用外科杂志 ›› 2012, Vol. 32 ›› Issue (11): 891-894.

• 专题笔谈 • 上一篇    下一篇

严重脓毒症致凝血功能障碍的新认识

章志丹   

  1. 中国医科大学附属第一医院重症医学科，辽宁沈阳110001
  • 出版日期:2012-11-01 发布日期:2012-10-19

  • Online:2012-11-01 Published:2012-10-19

PDF

摘要：

脓毒症常合并不同程度的凝血功能障碍。组织因子介导的促凝机制增强，生理抗凝机制下调以及纤溶系统功能抑制是脓毒症凝血功能障碍发生的主要机制。针对凝血系统功能障碍的不同机制给予针对性的药物治疗，对改善脓毒症病人的预后可能有益。

关键词: 脓毒症, 凝血功能障碍

Abstract:

New opinion of coagulation disorders resulted from severe sepsis        ZHANG Zhi-dan. Department of Intensive Care Unit, the First Affiliated Hospital of China Medical University，Shenyang 110001, China
Abstract    Sepsis is almost invariably associated with coagulation disorders. The mechanisms underlying septic coagulopathy including tissue factor induced enhancement of procoagulation, down-regulation of physical anticoagulation pathway and inhibition of fibrinolysis. Appropriate pharmacotherapy aiming directly at different mechanisms of septic coagulopathy may be effective for severe sepsis patients.

Key words: sepsis, coagulation disorders