关键词: 手术部位感染, 脓毒症, 腹腔感染, 皮肤软组织感染, 持续炎性反应与免疫抑制分解综合征, 慢重症

Abstract:

Advance of surgical infection research and its impact to the current surgical practice        REN Jian-an. Research Institute of General Surgery，Jinling Hospital，Nanjing University School of Medicine，Nanjing 210002，China
Abstract    Advances in surgical infection research improve the surgical clinical practice. Surgical site infection (SSI) is the most possible preventable hospital acquired infection. Preventive measures for the SSI include prophylactic antibiotics within two hours before operation，keeping warm during operation and remove of drains as early as possible. Adoption of oral antibiotics and bowel preparation before elective colectomy would reduce SSI. Resuscitation，organ function support and source controls are the most important measures in the management of surgical infection complicated with sepsis or septic shock. Percutaneous drainage of abscess and open abdomen therapy are the recent advances in the source control of intra-abdominal infection. Necrotic fasciitis is the most severe form of skin and soft tissue infections. Early radical debridement and appropriate antibiotics usage are the key points when managing the necrotic fasciitis. Persistent or recurrent infection is the leading cause of persistent inflammation and immunosuppression catabolism syndrome which may manifest as chronic critical illness. Source control，early enteral nutrition and early rehabilitation are the effective ways to prevent or reverse chronic critical illness.

Key words: surgical site infection, sepsis, intra-abdominal infection, skin and soft tissue infection, persistent inflammation-immunosuppression catabolism syndrome, chronic critical illness