关键词: 胃转移性肿瘤, 临床特征, 原发肿瘤, 分子特征, 个体化治疗

Abstract: Progress of metastatic neoplasms involving the stomach             LUO Dan-dong, XIONG Zhi-zhong, ZHONG Bin，et al. Department of General Surgery (Department of Gastrointestinal Surgery), the Affiliated Sixth Hospital of Sun Yat-sen University, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, the Sixth Affiliated Hospital, Sun Yat-sen University, Biomedical Innovation Center, the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China
Corresponding author： LIAN Lei,E-mail:lianlei2@mail.sysu.edu.cn
Abstract    Gastric cancer is one of the most common malignancies, but metastatic tumors involving the stomach are rare. Metastatic gastric tumors are often misdiagnosed as primary gastric malignancies due to a lack of understanding of past medical history and morphological features of the primary tumor. In addition to the challenges in diagnosis, the clinical management and prognosis of gastric metastatic tumors have not been fully summarized. The clinical symptoms of metastatic gastric tumors are atypical, and the primary malignant tumors are mostly breast cancer or malignant melanoma. History of primary tumor, endoscopy, and pathological biopsy are the best means to confirm gastric metastatic tumors. The prognosis of gastric metastatic tumors is poor, so individualized treatment based on the clinical, biological, and molecular characteristics of the primary tumor is often needed to improve the survival of patients further. For patients with complications such as bleeding, tumor perforation, or solitary metastasis, surgical treatment is necessary. Although surgical resection can alleviate symptoms and reduce tumor burden, the overall prognosis remains poor. The median survival time for patients with gastric metastases from highly invasive tumors such as malignant melanoma and breast cancer is short. Multiple studies have shown that the prognosis for patients with metastatic gastric tumors is poor, with an overall survival time of usually ≤1 year. Future research directions include an in-depth understanding of the clinical and molecular characteristics of primary tumors and gastric metastatic tumors. Utilizing multi-omics sequencing data to reveal the occurrence mechanisms and identify new therapeutic targets and predictive biomarkers could improve personalized treatment strategies and enhance patient survival rates and quality of life.

Key words: gastric metastatic tumors, clinical characteristics, primary tumors, molecular characteristics, personalized therapy