关键词: 胰腺癌, 新辅助治疗, 生物标记物, 影像学, 营养指标, 可切除性, 疗效评估

Abstract: Research progress in the response evaluation of neoadjuvant therapy for pancreatic cancer        LI Peng-yu, ZHANG Han-yu, DAI Meng-hua. Department of General Surgery, Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Beijing 100730,China 
Corresponding author：DAI Meng-hua, E-mail:daim66@126.com
Abstract    Pancreatic cancer has a poor prognosis for its high malignancy.Radical surgical resection is an effective means for prolonging survival.However，less than 20% of patients can be directly treated with surgical resection.At present，Neoadjuvant therapy can reduce the tumor size，improve the relationship between the tumor and adjacent blood vessels，to gain surgical opportunities and increase the rate of surgical resection，thereby prolonging survival.However，the evaluation strategy of neoadjuvant therapy response remains controversial.At present，CA19-9 and enhanced CT are commonly used in clinical practice，which can evaluate the efficacy of neoadjuvant therapy to a certain extent，but there are still some shortcomings.The exploration of other tumor markers and emerging biomarkers，the in-depth research of imaging such as PET and MRI，and the application of nutritional indicators have provided new perspectives for evaluating the efficacy of neoadjuvant therapy.With the gradual in-depth research and clinical verification in related fields，it is expected to accurately assess the effectiveness of neoadjuvant therapy for pancreatic cancer，thereby optimizing the comprehensive diagnosis and treatment strategy for patients with pancreatic cancer.

Key words: pancreatic cancer, neoadjuvant therapy, biomarkers, imaging examination, nutrition index, resectablility, response evaluation