关键词: 肝癌, 液体活检, 外科治疗, 临床试验, 诊疗规范

Abstract:

The advances in diagnosis，treatment and clinical research of hepatocellular carcinoma in China        FAN Jia. Liver Cancer Institute and Zhongshan Hospital，Fudan University，Shanghai 200032，China
Abstract    As one of the high frequent malignancies in China，liver cancer has different disease background and clinical management modalities compared with that in foreign countries. In recent years，China has made great progress in the diagnosis and treatment of liver cancer. In the early diagnosis，a series of accomplishments have been achieved in liquid biopsy techniques represented by circulating microRNA (miRNA), circulating tumor cell (CTC)，and circulating tumor DNA (ctDNA)，which remarkably promoted the early diagnosis of liver cancer. In the surgical treatment，through continuous exploration of novel surgical methods，surgical indications and anti-recurrence and -metastasis strategies，patients get more surgical opportunities，lower risks of metastasis and relapse and significantly prolonged overall survival. In addition，clinical research of liver cancer has received unprecedented attention. The conclusions of some clinical trials have served as important evidence to direct the development of guidelines，and to choose appropriate treatment strategies for patients in China，which is more in line with the characteristics of liver cancer in China.

Key words: hepatocellular carcinoma, liquid biopsy, surgical treatment, clinical trials, guidelines for diagnosis and treatment