关键词: 完全可吸收合成材料, 交联生物支架, 非交联生物支架, 补片

Abstract:

Some new understanding about biological materials used for hernia and abdominal wall surgery        MA Song-zhang. Department of Hernia and Abdominal Wall Surgery，Chaoyang Hospital of Capital Medical University，Beijing 100020，China
Abstract    Based on modified classification of surgical meshes for hernia repair which recommended by Europe Hernia Society，biological mesh and fully absorbable synthetic materials are combined to one class: biologicals. The healing process for biologicals material is biological degradation and remodeling process，which is different from synthetic material scar forming process. The current used crosslinked biologic mesh will slow the degradation of the implemented meshes，allow the mature collagen in regenerated tissue to be strong enough to support the tension from the defect repair area. If the control for the crosslink in manufacturing processes is not appropriate，it may result in reduced scaffold porosity and restricted host cell infiltration of the scaffold. The processes may lead to fibrous encapsulation rather than tissue remodeling of the biologic scaffold for an effective soft tissue repair. After non-crosslinked biologic mesh is imbedded，it will vascularize quickly and enter repair area with phagocyte，and demonstrate tolerance of infection mechanism. Once infection occurred，it is not necessary to take out the mesh. Non-crosslinked biologic mesh is the first choice for contamination incisional hernia. Compare to synthetic material，biological mesh is lack the mechanical strength of synthetic materials. That is the reason for new hybrid polypropylene ECM material coming to market.

Key words: fully absorbable synthetic materials, crosslinked biologic scaffolds, non-crosslinked biologic scaffolds, mesh