关键词: 胃腺癌, 病理分型, 黏液分泌, 黏液腺癌, 印戒细胞癌

Abstract: The current pathological classification methods for gastric adenocarcinoma are numerous and complex, but they have issues such as incomplete subtype coverage, insufficient focus, and limited prognostic relevance, which restrict their widespread application. Long-term clinical practice has revealed that mucus secretion is an important factor influencing the pathological characteristics and prognosis of gastric adenocarcinoma. Therefore, the authors’ team divided gastric adenocarcinoma into mucus-secretory adenocarcinoma (GMA) and non-mucus-secretory adenocarcinoma (GNMA) according to the situation of mucus secretion. Compared with GNMA, GMA is characterized by late TNM stage, rapid progression, easy invasion and metastasis, low radical resection rate, poor prognosis, and other pathological characteristics. Besides, there are many differences between GMA and GNMA in genetics, imaging, and therapeutic characteristics. The classification makes the subtyping of gastric adenocarcinoma clearer, has better value in clinical guidance, and may help promote the proposal and application of new pathological classifications to gastric cancer.

Key words: gastric adenocarcinoma, pathological classification, mucus secretion, mucinous adenocarcinoma, signet ring cell carcinoma