关键词: 甲状旁腺功能减退, 药物治疗

Abstract:

Drug therapy of postoperative hypoparathyroidism                    CHEN Xi, CHEN Hai-zhen. Department of General Surgery, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
Corresponding author：CHEN Xi, E-mail：cx10774@rjh.com.cn
Abstract    Calcium homeostasis is aimed in management of postsurgical hypoparathyroidism.When acute hypocalcemia need urgent treatment，iv calcium therapy is used to control symptoms，reverse signs and restore the serum calcium level to the lower end of the normal range. Standard long-term protocol of chronic hypoparathyroidism is oral calcium and active vitamin D supplementation，with thiazide diuretics if necessary，to maintain serum calcium in low normal reference and asymptomatic ranges，and to reduce the risk of complications，such as hypercalciuria，kidney stones，and ectopic calcification.Recombinant human PTH is only recommended for patients who cannot be well-controlled by conventional regimens.Orally active small-molecule PTHR1 agonist is in preclinical studies.

Key words: hypoparathyroidism, drug therapy