中国实用外科杂志

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低位直肠癌术前放化疗及疗效评价

杨立峰,章    真   

  1. 复旦大学附属肿瘤医院放疗中心  复旦大学上海医学院肿瘤学系,上海200032
  • 出版日期:2017-06-01 发布日期:2017-05-31

  • Online:2017-06-01 Published:2017-05-31

摘要:

低位直肠癌新辅助治疗模式的循证医学依据已在Ⅲ期随机临床研究中得到证实。在新辅助放疗模式日趋成熟应用的同时,对于现有治疗模式的局限性和治疗的毒性需要更多的优化,如新辅助治疗合适人群的选择;如何提高肿瘤的完全消退率,以提供实施“等待观察”的非手术治疗策略的机会,也对直肠癌新辅助放化疗的疗效评价提出了新的要求。

关键词: 低位直肠癌, 新辅助放化疗, 疗效评价

Abstract:

Effect of preoperative radiochemotherapy on the treatment of low rectal cancer        YANG Li-feng,ZHANG Zhen. Department of Radiation Oncology, Cancer Hospital, Fudan University;Department of Oncology, Shanghai Medical College, Fudan University,Shanghai200032,China
Corresponding author:ZHANG Zhen,E-mail:zhenzhang6@
gmail.com
Abstract    The evidence base of neoadjuvant therapy for low rectal cancer has been confirmed in a randomized phase Ⅲ study. In the neoadjuvant radiotherapy model is becoming more and more mature applications at the same time,the limitations of the existing mode of treatment and treatment toxicity needs more optimization,such as neoadjuvant therapy,appropriate choice of the patients; how to improve the complete remission rate of tumor,to provide the implementation of the non-operative treatment strategies “ wait & watch”. It also puts forward new requirements for the evaluation of neoadjuvant chemoradiotherapy for rectal cancer.

Key words: low rectal cancer, neoadjuvant radiochemotherapy, therapeutic evaluation