Abstract: Synthetic materials are commonly used to repair oral craniomaxillofacial hard tissue defects，however，the incompatibility of existing repair materials with human tissues affects the repair results. In order to achieve the structural and functional matching with human hard tissues，biomimetic design has become a promising direction for the development of synthetic materials in the field of oral craniomaxillofacial hard tissue repair and regeneration. This paper summarizes the research progress in this field in the recent 5 years and focuses on the design strategies of biomimetic repair materials and the application prospect in oral craniomaxillofacial hard tissue repair，aiming to improve the understanding of dental practitioners in this field and provide valuable references for the research and clinical application of structurally and functionally integrated oral restorative materials.

Key words: oral craniomaxillofacial hard tissue, biomimetic repair, bone defect, tissue engineering, micro-nano structure

摘要： 应用于口腔颅颌面硬组织缺损修复的人工合成材料，治疗效果常受到修复材料与人体组织不适配等多方面制约。为实现与人体硬组织结构功能相匹配，仿生设计已然成为修复材料研发中极具潜力的发展方向。文章通过总结该领域近5年的研究进展，重点探讨仿生修复材料的设计策略和在口腔颅颌面硬组织修复中的应用前景，旨在提高口腔医学工作者对该领域的理解，为结构功能一体化口腔修复材料的研发和临床应用提供有价值的参考。

关键词: 口腔颅颌面硬组织, 仿生修复, 骨缺损, 组织工程, 微纳结构