Abstract: The patients with severe periodontitis often have dentition defect and dentofacial deformities，and their normal oral function and appearance are seriously affected. With the demands of patients for restoration of oral health，function and aesthetics increasing，the treatment goals for severe periodontitis patients with dentofacial deformities should include establishing good occlusal contact，achieving sustained and stable periodontal health and taking into account masticatory function and restoration of dentofacial aesthetics. It usually requires complex multidisciplinary treatment，which is critical and difficult for clinical diagnosis and treatment. This article displays the multidisciplinary treatment procedures，including initial periodontal therapy，mucogingival surgery，orthodontic and orthognathic combined treatment，and a long-term follow-up of a patient with generalized stage Ⅲ grade C periodontitis and skeletal class Ⅲ malocclusion，which finally achieve the goals of restoring health，reconstructing function and esthetic improvement. It is expected to provide some experiences for the multidisciplinary treatment of clinical complex cases. 

Key words: severe periodontitis, multidisciplinary treatment, dentofacial deformity, mucogingival surgery

摘要： 重度牙周炎患者常伴有牙列缺损和牙颌面畸形，其正常的口腔功能和外形美观受到严重影响。随着患者对恢复口腔健康、功能及美观的要求不断提高，伴有牙颌面畸形的重度牙周炎患者的治疗目标需包含建立良好的咬合接触关系、达到持续稳定的牙周健康、兼顾咀嚼功能和牙颌面美观恢复。此类病例需要复杂的多学科联合治疗，是临床诊治的重点与难点。文章展示1例广泛型Ⅲ期C级牙周炎伴安氏Ⅲ类错牙合畸形患者通过牙周基础治疗、膜龈手术及正畸-正颌治疗在内的多学科联合治疗并长期随访，最终达到了恢复健康、重建功能和改善美观的治疗效果，以期为口腔临床复杂病例的多学科综合诊疗提供一定经验。

关键词: 重度牙周炎, 多学科治疗, 牙颌面畸形, 膜龈手术