Abstract: Dental local anesthesia is an essential step in most dental treatments，especially in oral surgery. Local anesthetic drugs are the primary option to determine the effectiveness of anesthesia and painless treatment. On the basis of pain-free treatment，a series of procedures，including tooth extraction，dental implantation，bone grafting，etc.，can be performed successfully. Since the middle of last century，the application of dental local anesthetic drugs and the concept of painless treatment has enabled various dental treatment modalities to be performed. In the long-term research and development in the field of biomedicine，dental local anesthesia drugs of China have also achieved the historical process from non-existence to existence and from existence to excellence. It has also brought China′s treatment of comfortization into a new era. The article gives a brief description of the development history of local anesthetic drugs applied to stomatology in China.

Key words: dental local anesthesia, drugs, comfortization, development

摘要： 口腔局部麻醉是大部分口腔治疗尤其是口腔外科治疗的重要步骤，而口腔局部麻醉药物是决定麻醉效果优劣及无痛治疗的首要选项。在无痛治疗的基础上，包括拔牙、种植、植骨等在内的一系列手术得以顺利进行。自20世纪中叶以来，口腔局部麻醉药物及无痛治疗理念的应用让各类口腔治疗方式得以施展。在长期的生物医药领域研发中，我国口腔局部麻醉药物也实现了从无到有、从有到优的历史进程，也让我国口腔舒适化治疗进入新的时代。文章就我国应用于口腔的局部麻醉药物的发展历程做一简述。

关键词: 口腔局部麻醉, 药物, 舒适化, 发展