Abstract: Periodontitis is a chronic inflammation that occurs in periodontal tissues，whose mainly manifestation are bleeding and swollen gums，periodontal pocket formation，loose teeth and alveolar bone resorption. Periodontitis is a common oral disease，which is one of the main causes of tooth loss in adults. In recent years，with the study on the periodontitis pathogenesis deepening，researchers have found that prostaglandin is a powerful stimulating factor for alveolar bone resorption，which can cause osteoclastic bone resorption. At the same time，drug research has found that non-steroidal anti-inflammatory drugs（NSAIDs）can inhibit the activity of cyclooxygenase and reduce the synthesis of prostaglandins，producing anti-inflammatory， analgesic and osteogenetic effects. Therefore，the therapeutic effects of non-steroidal anti-inflammatory drugs on periodontitis have also been studied in many clinical experimental studies. This review mainly focuses on the application of NSAIDs in the treatment of periodontitis.

Key words: periodontitis；non-steroidal anti-inflammatory drugs, NSAIDs；cyclooxygenase；prostaglandin

摘要： 牙周炎是发生在牙周组织的慢性感染性疾病，其主要临床表现为牙龈红肿出血、牙周袋形成、牙齿松动及牙槽骨吸收，是引起成年人牙齿丧失的主要原因之一。近年来，随着对牙周炎发病机制的深入研究发现，前列腺素是牙槽骨吸收强有力的刺激因子，使骨细胞发生破骨性吸收。同时，药物研究发现，非甾体抗炎药物（non-steroidal anti-inflammatory drugs，NSAIDs）能够抑制环氧酶，减少前列腺素的合成，从而产生抗炎、镇痛和成骨效果。因此，在临床上NSAIDs对牙周炎的治疗效果研究成为热点。文章就NSAIDs在牙周炎治疗中应用的研究进展做一综述。

关键词: 牙周炎, 非甾体抗炎药物, 环氧酶, 前列腺素